{4-[5-fluoro-4-(3-isopropyl-2-trifluoromethyl-3H-imidazol-4-yl)-pyrimidin-2-ylamino]-phenyl}-(4-methyl-piperazin-1-yl)-methanone hydrochloride | 934280-88-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: {4-[5-fluoro-4-(3-isopropyl-2-trifluoromethyl-3H-imidazol-4-yl)-pyrimidin-2-ylamino]-phenyl}-(4-methyl-piperazin-1-yl)-methanone hydrochloride
• 英文别名: [4-[[5-Fluoro-4-[3-propan-2-yl-2-(trifluoromethyl)imidazol-4-yl]pyrimidin-2-yl]amino]phenyl]-(4-methylpiperazin-1-yl)methanone;hydrochloride
• CAS: 934280-88-3
• 化学式: C₂₃H₂₅F₄N₇O*ClH
• 分子量: 527.952
• InChiKey: KFJPNBMHBFCMGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.63
• 重原子数：
  36
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  79.2
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• Use of Pyrimidine Derivatives in the Manufacture of a Medicament for Prevention and/or Treatment of Alzheimer's Disease
  申请人：Andersson Lars

  公开号：US20080214560A1

  公开（公告）日：2008-09-04

  Pyrimidine derivatives of formula I, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are as defined in the specification, as a base or a pharmaceutically acceptable salt thereof in the manufacture of pharmaceutical compositions and in the treatment or prophylaxis of Alzheimer's Disease.

  根据规范，作为制备药物组合物和治疗或预防阿尔茨海默病，I型嘧啶衍生物，其中R1、R2、R3、R4、R5、R6、R7、R8和R9按规范定义，作为碱或药用可接受的盐。
• Pyrimidine Derivatives and Their Use for Treating Bone-Related Disorders
  申请人：Andersson Lars

  公开号：US20110028489A1

  公开（公告）日：2011-02-03

  The present invention relates to a new use of pyrimidine derivatives of formula I, as a free base or a pharmaceutically acceptable salt thereof in the manufacture of a medicament in the treatment and/or prophylaxis of Alzheimer's Disease:

  本发明涉及使用式I的嘧啶衍生物，作为其自由碱基或药学上可接受的盐，在制造治疗和/或预防阿尔茨海默病的药物中的新用途：
• USE OF PYRIMIDINE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR PREVENTION AND/OR TREATMENT OF ALZHEIMER'S DISEASE
  申请人：AstraZeneca AB

  公开号：EP1942897A1

  公开（公告）日：2008-07-16
• [EN] USE OF PYRIMIDINE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR PREVENTION AND/OR TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] UTILISATION DE DERIVES DE PYRIMIDINE DANS LA PRODUCTION D'UN MEDICAMENT POUR LA PREVENTION ET/OU LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：ASTRAZENECA AB

  公开号：WO2007040436A1

  公开（公告）日：2007-04-12

  [EN] The present invention relates to a new use of pyrimidine derivatives of formula I, as a free base or a pharmaceutically acceptable salt thereof in the manufacture of a medicament in the treatment and/or prophylaxis of Alzheimer's Disease:
  [FR] L'invention concerne une nouvelle utilisation de dérivés de pyrimidine de formule (I) en tant que base libre ou un sel acceptable sur le plan pharmaceutique de ceux-ci dans la production d'un médicament utilisé dans le traitement et/ou la prophylaxie de la maladie d'Alzheimer.