1-(Diethylamino)-3-propoxypropan-2-ol | 32972-02-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(Diethylamino)-3-propoxypropan-2-ol
• CAS: 32972-02-4
• 化学式: C₁₀H₂₃NO₂
• 分子量: 189.298
• InChiKey: BFAZSAWYBJCZTB-UHFFFAOYSA-N

物化性质

• 沸点：
  266.3±25.0 °C(Predicted)
• 密度：
  0.922±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,2-环氧-3-(二乙基氨基)丙烷 、 丙醇 在 四氯化锡 作用下， 反应 10.0h， 以69%的产率得到1-(Diethylamino)-3-propoxypropan-2-ol
  参考文献：
  名称：

  Synthesis and uterostimulating activity of derivatives of 1-dialkylamino-3-alkoxy-2-propanol

  摘要：

  DOI：

  10.1007/bf00772007

文献信息

• CHROMATOGRAPHIC COLUMNS AND SEPARATION DEVICES COMPRISING A SUPERFICIALLY POROUS MATERIAL; AND USE THEREOF FOR SUPERCRITICAL FLUID CHROMATOGRAPHY AND OTHER CHROMATOGRAPHY
  申请人：Waters Technologies Corporation

  公开号：EP3936226A2

  公开（公告）日：2022-01-12

  The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are superficially porous chromatographic particulate materials comprising sized less than 2 microns.

  本发明提供了新型色谱材料，例如用于色谱分离的色谱材料、其制备工艺和含有该色谱材料的分离装置；包含该色谱材料的分离装置、色谱柱和试剂盒；以及其制备方法。本发明的色谱材料是表面多孔的色谱颗粒材料，其尺寸小于 2 微米。
• Chromatographic materials
  申请人：Waters Technologies Corporation

  公开号：US11059026B2

  公开（公告）日：2021-07-13

  In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.

  一方面，本发明提供了一种用于各种不同色谱模式的色谱固定相材料，由式 1 表示：[X](W)a(Q)b(T)c（式 1）。X 可以是一种高纯度色谱核心组合物，其表面由二氧化硅核心材料、金属氧化物核心材料、无机-有机混合材料或其嵌段共聚物组构成。W 可以不存在和/或包括氢和/或包括 X 表面上的羟基。Q 可以是一种官能团，在利用低浓度水的色谱条件下，可使保留随时间的变化（漂移）最小化。T 可包括一个或多个亲水、极性、可电离和/或带电的官能团，这些官能团可与分析物发生色谱相互作用。此外，b 和 c 可以是正数，比值为 0.05≤（b/c）≤100，a≥0。
• CHROMATOGRAPHIC MATERIALS
  申请人：Waters Technologies Corporation

  公开号：US20190217273A1

  公开（公告）日：2019-07-18

  In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W) a (Q) b (T) c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.
• US5021532A
  申请人：——

  公开号：US5021532A

  公开（公告）日：1991-06-04
• Synthesis and uterostimulating activity of derivatives of 1-dialkylamino-3-alkoxy-2-propanol
  作者：L. M. Zaitsev、Yu. V. Korotkii、I. I. Krasavtsev、M. O. Lozinskii

  DOI：10.1007/bf00772007

  日期：1991.7