pyrido<3,4-g>isoquinoline | 51521-29-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: pyrido<3,4-g>isoquinoline
• 英文别名: 2,6-diazaanthracene；2,6-diazaantracene；pyrido[3,4-g]isoquinoline
• CAS: 51521-29-0
• 化学式: C₁₂H₈N₂
• mdl: MFCD18448558
• 分子量: 180.209
• InChiKey: CXKVSEWPNCOXRI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  S(-)-o'-(1,1'-binaphthyl-2,2'-diyl)bis(diphenylphosphane)platinum(II) triflate 、 pyrido<3,4-g>isoquinoline 以 丙酮 为溶剂， 以84%的产率得到
  参考文献：
  名称：

  合成手性纳米组件的设计与研究。光学活性杂化、碘-过渡金属和全过渡金属大环分子方块的制备和表征

  摘要：

  描述了通过配位键结合在一起的各种光学活性纳米级四核组件的合成和表征。双[4-(4'-吡啶基)苯基]碘鎓三氟甲磺酸盐和手性过渡金属(Pd(II)或Pt(II))双膦的双三氟甲磺酸盐的相互作用导致形成手性混合碘-过渡金属分子方块。在这些方块中检测到配位的双 [4-(4'-吡啶基) 苯基] 碘鎓部分的受限旋转，并通过使用变温 NMR 进行了研究。使用上述双膦和双(3-吡啶基)碘三氟甲磺酸盐制备在组装中具有螺旋性(扭曲)元素的手性杂化方块。

  DOI：

  10.1021/ja961444r
• 作为产物：
  描述：

  N-[[4-[(2,2-dimethoxyethylamino)methyl]phenyl]methyl]-2,2-dimethoxyethanamine 生成 pyrido<3,4-g>isoquinoline
  参考文献：
  名称：

  SCHWAN, T. J.;GRAY, J. E.

  摘要：

  DOI：

文献信息

• Anti-cancer agents, compositions and methods of treating cancers
  申请人：Lam Marina K.

  公开号：US20080255175A1

  公开（公告）日：2008-10-16

  Compounds and compositions useful in methods for treating cancer in mammals. The compounds of the invention are of the formula: or a pharmaceutically acceptable salt, entantiomer or disastereomer thereof, wherein the “A” ring is a nitrogen-aryl group; each occurrence of Y is independently oxygen or H 2 ; Z is oxygen or —CH 2 —; X is nitrogen or —CH; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are subsitutents; n is an integer from 1-7; m is an integer having a value of 1-5; and the dotted line represents an optional bond.

  在治疗哺乳动物癌症方法中有用的化合物和组合物。发明的化合物的公式为： 或其药学上可接受的盐、对映体或二对映体，其中“A”环是一个氮芳基团； 每个Y的出现独立地是氧或H2； Z是氧或—CH2—； X是氮或—CH； R1、R2、R3、R4、R5、R6和R7是取代基； n是1-7之间的整数； m是一个值为1-5的整数；以及 虚线代表一个可选键。
• [EN] MODULATORS OF THE GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-KB ACTIVITY AND USE THEREOF<br/>[FR] MODULATEURS DU RECEPTEUR GLUCOCORTICOIDE AP-1, ET/OU DE L'ACTIVITE DE NF- DOLLAR G(K)B, ET LEUR UTILISATION
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2005072732A1

  公开（公告）日：2005-08-11

  A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-ĸB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I) its stereoisomers thereof, or a solvate thereof, or a prodrug thereof, or a pharmaceutically acceptable salt thereof, where Z is CONR1R2 or CH2NR1R2 and where at least one of X1 - X8 is N, and R, Ra, Rb, Rc and Rd are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.

  提供了一类新型非类固醇化合物，可用于治疗与糖皮质激素受体、AP-1和/或NF-ĸB活性调节相关的疾病，包括肥胖、糖尿病、炎症和免疫性疾病，其结构如公式（I）所示，其立体异构体，或其溶剂化物，或其前药，或其药用可接受盐，其中Z为CONR1R2或CH2NR1R2，其中至少一个X1-X8为N，R、Ra、Rb、Rc和Rd在此处定义。还提供了包含所述化合物的药物组合物和治疗肥胖、糖尿病和炎症或免疫相关疾病的方法。
• A Convenient Synthesis of Pyrido[3,4-<i>g</i>]isoquinoline via<i>ortho</i>-Directed Metallation/Dimerization
  作者：Véronique Bolitt、Charles Mioskowski、S. Pulla Reddy、J. R. Falck

  DOI：10.1055/s-1988-27584

  日期：——

  A practical synthesis of pyrido[3,4-g]isoquinoline was realized by a novel ortho-metallation/dimerization of N,N-diethylnicotinamide (or N,N-diethylisonicotinamide), hydriodic acid reduction of the resultant diazaanthraquinone, and catalytic dehydrogenation.

  通过N,N-二乙基烟酰胺（或N,N-二乙基异烟酰胺）的新型邻位金属化/二聚、所得二氮杂蒽醌的氢碘酸还原和催化脱氢，实现了吡啶并[3,4-g]异喹啉的实际合成。
• Organic photochromic compound, a dimer of pyrido quinoline
  申请人：Seikisui Kagaku Kogyo Kabushiki Kaisha

  公开号：US05091535A1

  公开（公告）日：1992-02-25

  An organic photochromic compound with improved long term preservability, thermal stability, the repetition character of the record and the like and useful as recording-memory materials or photosensitizers, comprising dimers of the compounds selected from the group consisting of pyrido[3,4-g]isoquinoline, pyrido[2,3-g]quinoline, pyrido[3,2-g]quinoline and pyrido[3,2-g]quinoline derivatives.

  一种有机光致变色化合物，具有改善的长期保藏性、热稳定性、记录的重复性等特点，可用作记录记忆材料或光敏剂，包括从吡啶并[3,4-g]异喹啉、吡啶并[2,3-g]喹啉、吡啶并[3,2-g]喹啉和吡啶并[3,2-g]喹啉衍生物组成的化合物二聚体。
• Modulators of the glucocorticoid receptor, AP-1, and/or NF-kB activity and use thereof
  申请人：Duan Jingwu

  公开号：US20050182082A1

  公开（公告）日：2005-08-18

  A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I) its stereoisomers thereof, or a solvate thereof, or a prodrug thereof, or a pharmaceutically acceptable salt thereof, where Z is CONR 1 R 2 or CH 2 NR 1 R 2 and where at least one of X 1 -X 8 is N, and R, R a , R b , R c and R d are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.

  提供了一类新型的非甾体化合物，可用于治疗与糖皮质激素受体、AP-1和/或NF-κB活性调节相关的疾病，包括肥胖症、糖尿病、炎症和免疫性疾病，其结构式为（I）及其立体异构体、溶剂化物、前药或药物可接受的盐，其中Z为CONR1R2或CH2NR1R2，而X1-X8中至少有一个为N，R、Ra、Rb、Rc和Rd在此定义。还提供了药物组合物和治疗肥胖症、糖尿病和炎症或免疫相关疾病的方法，包括上述化合物。