2-pyrimidyl-6-bromopyridine | 1030367-00-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类 - 二氮杂萘
• 英文名称: 2-pyrimidyl-6-bromopyridine
• 英文别名: 1-(6-Bromopyridin-2-yl)perimidine；1-(6-bromopyridin-2-yl)perimidine
• CAS: 1030367-00-0
• 化学式: C₁₆H₁₀BrN₃
• 分子量: 324.18
• InChiKey: QINKAIXTQGICNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,6-二溴吡啶 、 呸啶 在 copper(l) iodide potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以62%的产率得到2-pyrimidyl-6-bromopyridine
  参考文献：
  名称：

  CuI/L (L=pyridine-functionalized 1,3-diketones) catalyzed C–N coupling reactions of aryl halides with NH-containing heterocycles

  摘要：

  An efficient copper-catalyzed N-arylation and N-heteroarylation reactions of imidazole, pyrrole, indole, pyrazole, and perimidine with aryl or heteroaryl halides using pyridine-functionalized 1,3-diketone as ligands have been investigated. The ligands bearing pyridyl and 1,3-diketone moieties. which may form chelated Cu(I) species, are inexpensive and readily available. The combination of CuI and 1,3-di(pyridin-2-yl)propane- 1-3-dione is very efficient for C-N coupling reactions to afford various N-arylated products in good to excellent yields. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.02.082

文献信息

• CuI/L (L=pyridine-functionalized 1,3-diketones) catalyzed C–N coupling reactions of aryl halides with NH-containing heterocycles
  作者：Zhenxing Xi、Fenghui Liu、Yongbo Zhou、Wanzhi Chen

  DOI：10.1016/j.tet.2008.02.082

  日期：2008.5

  An efficient copper-catalyzed N-arylation and N-heteroarylation reactions of imidazole, pyrrole, indole, pyrazole, and perimidine with aryl or heteroaryl halides using pyridine-functionalized 1,3-diketone as ligands have been investigated. The ligands bearing pyridyl and 1,3-diketone moieties. which may form chelated Cu(I) species, are inexpensive and readily available. The combination of CuI and 1,3-di(pyridin-2-yl)propane- 1-3-dione is very efficient for C-N coupling reactions to afford various N-arylated products in good to excellent yields. (c) 2008 Elsevier Ltd. All rights reserved.