4-(((8R,9S,13S,14S,17S)-3-(methoxymethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl)oxy)-4-oxobutanoic acid | 151869-48-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 4-(((8R,9S,13S,14S,17S)-3-(methoxymethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl)oxy)-4-oxobutanoic acid
• CAS: 151869-48-6
• 化学式: C₂₄H₃₂O₆
• 分子量: 416.514
• InChiKey: BXKKQSXSXINSLZ-RUFWAXPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  30.0
• 可旋转键数：
  7.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  82.06
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  4-(((8R,9S,13S,14S,17S)-3-(methoxymethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl)oxy)-4-oxobutanoic acid 、 (氨基亚甲基)双磷酸四乙酯 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 10.0h， 生成 (8R,9S,13S,14S,17S)-3-(methoxymethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl 4-((bis(diethoxyphosphoryl)methyl)amino)-4-oxobutanoate
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of novel estradiol–bisphosphonate conjugates as bone-specific estrogens

  摘要：

  Bone deficiency causes osteoporosis and often decreases quality of life in patients with rheumatoid arthritis. Estrogens are known to protect elderly women from bone loss. Synthesis of new estradiol-bisphosphonate conjugates (E-2-BPs) was accomplished and their in vivo activity as bone-specific estrogens were examined. Among them, MCC-565 showed selective estrogenic activity in bones; but it showed little estrogenic activity in the uterus. We also found that the linker moiety in E2-BPs was essential for the absorption and specificity of the conjugates. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.12.041
• 作为产物：
  描述：

  丁二酸酐 、 estra-1,3,5(10)-triene-3,17β-diol 3-methoxymethyl ether 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 10.0h， 生成 4-(((8R,9S,13S,14S,17S)-3-(methoxymethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl)oxy)-4-oxobutanoic acid
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of novel estradiol–bisphosphonate conjugates as bone-specific estrogens

  摘要：

  Bone deficiency causes osteoporosis and often decreases quality of life in patients with rheumatoid arthritis. Estrogens are known to protect elderly women from bone loss. Synthesis of new estradiol-bisphosphonate conjugates (E-2-BPs) was accomplished and their in vivo activity as bone-specific estrogens were examined. Among them, MCC-565 showed selective estrogenic activity in bones; but it showed little estrogenic activity in the uterus. We also found that the linker moiety in E2-BPs was essential for the absorption and specificity of the conjugates. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.12.041