2-methyl-8-nitro-2,3-dihydro-phthalazine-1,4-dione | 192511-86-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-methyl-8-nitro-2,3-dihydro-phthalazine-1,4-dione
• 英文别名: 8-Nitro-2-methyl-2,3-dihydro-1,4-phthalazindion；2-Methyl-8-nitro-2,3-dihydro-phthalazin-1,4-dion
• CAS: 192511-86-7
• 化学式: C₉H₇N₃O₄
• 分子量: 221.172
• InChiKey: YGWHJZYSENIDMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.14
• 重原子数：
  16.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  98.0
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  2-methyl-8-nitro-2,3-dihydro-phthalazine-1,4-dione 在 盐酸 、 tin 作用下， 生成 2-Methyl-8-amino-2,3-dihydro-1,4-phthalazindion
  参考文献：
  名称：

  Persistent, Consistent, Widespread, and Robust? Another Look at Recent Trends in Old-Age Disability

  摘要：

  Objective. The purpose of this study was to provide new evidence on disability trends among elderly persons from 1982 to 1996.Methods. The sample includes 125,949 participants aged 70 and older in the 1982-1996 National Health Interview Surveys. Logistic analysis was used to estimate the trend in disability prevalence after controlling for various sociodemographic factors.Results. We found that: (a) the prevalence of disability has declined, but the gains did not persist throughout the entire period or accelerate over time: (b) only routine care disability has declined. whereas more severe personal care disability shows no improvements; (c) estimates are robust to the exclusion of the nursing home population but may be sensitive to growth in the assisted living population: (d) estimates of decline in disability prevalence are fairly consistent across five national surveys: (e) gains have been concentrated among the most educated elderly persons: and (F) gains in education appear to be an important confounder of the improvements.Discussion. Evidence from several surveys using various measures indicate that disability has declined among elderly persons. Determining the causes of the improvements should be a high priority in future research efforts.

  DOI：

  10.1093/geronb/56.4.s206
• 作为产物：
  描述：

  3-硝基邻苯二甲酰亚胺 、 甲基肼 在 N,N-二异丙基乙胺 作用下， 以 乙醇 为溶剂， 生成 2-methyl-8-nitro-2,3-dihydro-phthalazine-1,4-dione
  参考文献：
  名称：

  组合裂解和脱保护方案的实施。1.邻苯二甲酰肼库的合成

  摘要：

  邻苯二甲酰肼库是由取代的肼和邻苯二甲酰亚胺以几种不同的库格式在溶液中合成的，包括单一化合物，索引子库和完整的库。当在固相合成过程中进行时，这种组合的裂解和脱保护方案为生成取代的邻苯二甲酰肼的多样化文库提供了可能性。

  DOI：

  10.1016/0040-4039(96)00544-8

文献信息

• The Chemiluminescence of Phthalhydrazide Derivatives¹
  作者：Carl N. Zellner、Gregg Dougherty

  DOI：10.1021/ja01291a031

  日期：1937.12
• 388. Chemiluminescent organic compounds. Part V. The methyl derivatives of 5-nitro- and 5-amino-phthalaz-1 : 4-dione. Structural features in relation to chemiluminescence
  作者：H. D. K. Drew、R. F. Garwood

  DOI：10.1039/jr9370001841

  日期：——
• The Methyl and Phenyl Derivatives of the Nitrophthalhydrazides
  作者：C. N. Zellner、Gregg Dougherty

  DOI：10.1021/ja01300a090

  日期：1936.9