9-benzyl-8-pyrazol-1-yl-9H-purin-6-ylamine | 855767-71-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-benzyl-8-pyrazol-1-yl-9H-purin-6-ylamine
• 英文别名: 9-benzyl-8-pyrazol-1-ylpurin-6-amine
• CAS: 855767-71-4
• 化学式: C₁₅H₁₃N₇
• 分子量: 291.315
• InChiKey: KLJNWEQPZAXMRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  87.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  9-benzyl-8-pyrazol-1-yl-9H-purin-6-ylamine 在 10% palladium on activated carbon 甲酸 、 甲酸铵 作用下， 以 甲醇 为溶剂， 反应 24.5h， 生成 8-pyrazol-1-yl-9H-purin-6-ylamine
  参考文献：
  名称：

  [EN] PURINE COMPOUNDS WHICH CAN BE USED AS PHOSPHODIESTERASE (PDE) TYPE IV INHIBITORS
  [FR] INHIBITEURS DE LA PHOSPHODIESTERASE

  摘要：

  公开号：

  WO2005058898A3
• 作为产物：
  描述：

  吡唑 、 9-苄基-8-溴-9H-嘌呤-6-胺 在 sodium hydride 、 水 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 22.0h， 生成 9-benzyl-8-pyrazol-1-yl-9H-purin-6-ylamine
  参考文献：
  名称：

  [EN] PURINE COMPOUNDS WHICH CAN BE USED AS PHOSPHODIESTERASE (PDE) TYPE IV INHIBITORS
  [FR] INHIBITEURS DE LA PHOSPHODIESTERASE

  摘要：

  公开号：

  WO2005058898A3

文献信息

• Phosphodiesterase Inhibitors
  申请人：Palle Venkata P.

  公开号：US20080280926A1

  公开（公告）日：2008-11-13

  The present invention relates to purine derivatives, which can be used as selective phosphodiesterase (PDE) type IV inhibitors. Compounds disclosed herein can be useful in the treatment of asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Also provided are processes for the preparation of disclosed compounds, pharmaceutical composition containing the disclosed compounds and their use as selective phosphodiesterase (PDE) type IV inhibitors.

  本发明涉及嘌呤衍生物，可用作选择性磷酸二酯酶（PDE）IV型抑制剂。本文所披露的化合物可用于治疗哮喘、关节炎、支气管炎、慢性阻塞性肺疾病（COPD）、银屑病、过敏性鼻炎、休克、特应性皮炎、克罗恩病、成人呼吸窘迫综合征（ARDS）、嗜酸性肉芽肿、过敏性结膜炎、骨关节炎、溃疡性结肠炎和其他炎症性疾病，尤其是在人类中。还提供了制备所述化合物的方法、含有所述化合物的制药组合物以及它们作为选择性磷酸二酯酶（PDE）IV型抑制剂的用途。
• PURINE COMPOUNDS WHICH CAN BE USED AS PHOSPHODIESTERASE (PDE) TYPE IV INHIBITORS
  申请人：Ranbaxy Laboratories Limited

  公开号：EP1697363A2

  公开（公告）日：2006-09-06
• [EN] PHOSPHODIESTERASE INHIBITORS<br/>[FR] INHIBITEURS DE LA PHOSPHODIESTERASE
  申请人：RANBAXY LAB LTD

  公开号：WO2005058898A2

  公开（公告）日：2005-06-30

  The present invention relates to purine derivatives, which can be used as selective phosphodiesterase (PDE) type IV inhibitors. Compounds disclosed herein can be useful in the treatment of asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Also provided are processes for the preparation of disclosed compounds, pharmaceutical composition containing the disclosed compounds and their use as selective phosphodiesterase (PDE) type IV inhibitors.
• [EN] PURINE COMPOUNDS WHICH CAN BE USED AS PHOSPHODIESTERASE (PDE) TYPE IV INHIBITORS<br/>[FR] INHIBITEURS DE LA PHOSPHODIESTERASE
  申请人：RANBAXY LAB LTD

  公开号：WO2005058898A3

  公开（公告）日：2005-08-11