4-(naphth-2-yl)benzyl bromide | 344797-47-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-(naphth-2-yl)benzyl bromide
• 英文别名: 2-[4-(Bromomethyl)phenyl]naphthalene
• CAS: 344797-47-3
• 化学式: C₁₇H₁₃Br
• 分子量: 297.194
• InChiKey: HZZCLRZKVBUUNO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  4-(naphth-2-yl)benzyl bromide 、 4-phenoxy-N-(piperidine-4-yl)benzamide 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 20.0h， 生成
  参考文献：
  名称：

  Evaluation of NovelN-(piperidine-4-yl)benzamide Derivatives as Potential Cell Cycle Inhibitors in HepG2 Cells

  摘要：

  In this study, a series of novel N‐(piperidine‐4‐yl)benzamide derivatives was designed, synthesized, and evaluated for antitumor activity. Some compounds were found to have potent antitumor activity. In particular, compound 47 showed the most potent biological activity against HepG2 cells, with an IC50 value of 0.25 μm. Western blot analysis demonstrated that compound 47 inhibited the expression of cyclin B1 and p‐Rb and enhanced the expression of p21, p53, Rb, and phospho‐adenosine monophosphate‐activated protein kinase (p‐AMPK). Further, cell cycle arrest was observed by flow cytometry (FCM). In summary, compound 47 was screened to have potential activity for the treatment of hepatocarcinoma via the induction of cell cycle arrest by a p53/p21‐dependent pathway.

  DOI：

  10.1111/cbdd.12484

文献信息

• US5385912A
  申请人：——

  公开号：US5385912A

  公开（公告）日：1995-01-31
• US5494918A
  申请人：——

  公开号：US5494918A

  公开（公告）日：1996-02-27
• [EN] MULTICYCLIC TERTIARY AMINE POLYAROMATIC SQUALENE SYNTHETASE INHIBITORS
  申请人：RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC.

  公开号：WO1992015579A1

  公开（公告）日：1992-09-17

  (EN) This invention relates to polycyclic compounds containing two mono and/or bicyclic rings and a basic tertiary amino group capable of forming an ammonium ion at biological pH and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.(FR) L'invention se rapporte à des composés polycycliques contenant deux chaînes monocycliques et/ou bicycliques et un groupe aminé tertiaire basique qui est capable de former an ion ammonium à un pH biologique et qui réduit les niveaux de cholestérol séral dans l'organisme sans réduire de façon sensible la synthèse des métabolites mévaloniques. L'invention se rapporte également à des compositions pharmacologiques et à des procédés de traitement pour abaisser les niveaux de cholestérol séral au moyen desdits composés.