phosphoric acid mono-{2-[1-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-2-oxo-ethoxy]-3-oxo-propyl} ester | 63436-28-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: phosphoric acid mono-{2-[1-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-2-oxo-ethoxy]-3-oxo-propyl} ester
• 英文别名: [(2R)-2-[(1R)-1-(2-amino-6-oxo-1H-purin-9-yl)-2-oxoethoxy]-3-oxopropyl] dihydrogen phosphate
• CAS: 63436-28-2
• 化学式: C₁₀H₁₂N₅O₈P
• 分子量: 361.208
• InChiKey: TUZMWYKHGVHBFZ-NTSWFWBYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  195
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• [EN] MRNA CAP ANALOGS AND METHODS OF MRNA CAPPING<br/>[FR] ANALOGUES DE COIFFES ARNM ET PROCÉDÉS DE COIFFAGE D'ARNM
  申请人：MODERNATX INC

  公开号：WO2017066793A1

  公开（公告）日：2017-04-20

  The present disclosure relates to cap analogs of formula (I) as defined in claim 1, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.

  本公开涉及公式（I）中定义的帽子类似物，其可以导致高水平的帽子效率和转录以及改善的翻译效率。本公开还涉及用于制备帽子类似物和使用包含此类类似物的mRNA物种的方法，以及包含新型帽子类似物的试剂盒。
• TRINUCLEOTIDE MRNA CAP ANALOGS
  申请人：ModernaTX, Inc.

  公开号：US20190211368A1

  公开（公告）日：2019-07-11

  The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.

  本公开涉及盖帽类似物，可以导致高水平的盖帽效率和转录以及改善翻译效率。本公开还涉及用于制备盖帽类似物和使用含有这种类似物的mRNA物种的有用方法，以及包含新型盖帽类似物的试剂盒。
• MRNA CAP ANALOGS AND METHODS OF MRNA CAPPING
  申请人：ModernaTX, Inc.

  公开号：US20190225644A1

  公开（公告）日：2019-07-25

  The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.
• [EN] MRNA CAP ANALOGS WITH MODIFIED SUGAR<br/>[FR] ANALOGUES DE COIFFE D'ARNM AVEC SUCRE MODIFIÉ
  申请人：MODERNATX INC

  公开号：WO2017066789A1

  公开（公告）日：2017-04-20

  The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.
• [EN] TRINUCLEOTIDE MRNA CAP ANALOGS<br/>[FR] ANALOGUES DE COIFFES D'ARNM TRINUCLÉOTIDIQUES
  申请人：MODERNATX INC

  公开号：WO2017066797A1

  公开（公告）日：2017-04-20

  The present disclosure relates to cap analogs of formula (I) as defined in claim 1, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.