(3R,4R)-3-[(2R)-2-(4-fluorophenyl)-2-hydroxyethylthio]-4-(2,4-dihydroxyphenyl)-1-[4-(5-chloropyridin-3-yl)phenyl]azetidin-2-one | 1056208-78-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: (3R,4R)-3-[(2R)-2-(4-fluorophenyl)-2-hydroxyethylthio]-4-(2,4-dihydroxyphenyl)-1-[4-(5-chloropyridin-3-yl)phenyl]azetidin-2-one
• 英文别名: (3R,4R)-1-[4-(5-chloropyridin-3-yl)phenyl]-4-(2,4-dihydroxyphenyl)-3-[(2R)-2-(4-fluorophenyl)-2-hydroxyethyl]sulfanylazetidin-2-one
• CAS: 1056208-78-6
• 化学式: C₂₈H₂₂ClFN₂O₄S
• 分子量: 537.011
• InChiKey: KNYOWOLZJSLNSZ-OYUWMTPXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  119
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• 1-BIARYLAZETIDINONE DERIVATIVE
  申请人：Nakano Akira

  公开号：US20100125059A1

  公开（公告）日：2010-05-20

  The object of the present invention is to provide a compound having an excellent cholesterol-lowering effect and to provide a drug for the treatment, prevention of onset, or prevention of progress of lipid metabolism disorder, hyperlipidemia, or atherosclerosis. A compound represented by formula (I) or a pharmaceutically acceptable salt thereof; or a medicament or a pharmaceutical composition, which contain the compound or the salt as an active ingredient.

  本发明的目的是提供一种具有出色的降低胆固醇作用的化合物，并提供一种用于治疗、预防脂质代谢紊乱、高脂血症或动脉粥样硬化的药物。该化合物由式(I)表示或其药学上可接受的盐；或包含该化合物或盐作为活性成分的药物或制药组合物。
• 1-BIARYLAZETIDINONE DERIVATIVES
  申请人：Teijin Pharma Limited

  公开号：EP2133347A1

  公开（公告）日：2009-12-16

  The object of the present invention is to provide a compound having an excellent cholesterol-lowering effect and to provide a drug for the treatment, prevention of onset, or prevention of progress of lipid metabolism disorder, hyperlipidemia, or atherosclerosis. A compound represented by formula (I) or a pharmaceutically acceptable salt thereof; or a medicament or a pharmaceutical composition, which contain the compound or the salt as an active ingredient.

  本发明的目的是提供一种具有优异降胆固醇效果的化合物，并提供一种用于治疗、预防脂质代谢紊乱、高脂血症或动脉粥样硬化症的发生或防止其进展的药物。 一种由式（I）代表的化合物或其药学上可接受的盐；或一种药物或药物组合物，其中含有该化合物或该盐作为活性成分。