6-Methyl-1,7-dihydro-2H-pyrrolo[2,3-d]pyrimidin-2-one | 663597-69-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 6-Methyl-1,7-dihydro-2H-pyrrolo[2,3-d]pyrimidin-2-one
• 英文别名: 6-methyl-1,7-dihydropyrrolo[2,3-d]pyrimidin-2-one
• CAS: 663597-69-1
• 化学式: C₇H₇N₃O
• mdl: MFCD10686999
• 分子量: 149.15
• InChiKey: QANYZFPLMHQWJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  57.2
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• [EN] HEPATITIS C VIRUS INHIBITORS<br/>[FR] INHIBITEURS DU VIRUS DE L'HÉPATITE C
  申请人：ENANTA PHARM INC

  公开号：WO2010099527A1

  公开（公告）日：2010-09-02

  The present invention discloses compounds or pharmaceutically acceptable salts, esters, or prodrugs thereof, which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

  本发明公开了抑制RNA含病毒，特别是丙型肝炎病毒（HCV）的化合物或药用可接受的盐、酯或前药，因此，本发明的化合物干扰丙型肝炎病毒的生命周期，并且也可用作抗病毒剂。本发明还涉及包含上述化合物的药物组合物，用于治疗患有HCV感染的受试者。该发明还涉及通过给予包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。
• [EN] OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF<br/>[FR] COMPOSITIONS D'OLIGONUCLÉOTIDES ET PROCÉDÉS ASSOCIÉS
  申请人：WAVE LIFE SCIENCES LTD

  公开号：WO2022099159A1

  公开（公告）日：2022-05-12

  Among other things, the present disclosure provides oligonucleotides and compositions thereof. In some embodiments, provided oligonucleotides and compositions are useful for adenosine modification. In some embodiments, the present disclosure provides methods for treating various conditions, disorders or diseases that can benefit from adenosine modification.

  除其他事项外，本公开提供寡核苷酸及其组合物。在某些实施例中，提供的寡核苷酸及其组合物对腺苷修饰有用。在某些实施例中，本公开提供了治疗各种需要腺苷修饰的疾病、疾病或病症的方法。
• Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules
  申请人：Haystack Sciences Corporation

  公开号：US11186836B2

  公开（公告）日：2021-11-30

  The present disclosure relates to multifunctional molecules, including molecules according to formula (I): ([(B1)M-D-L1]Y-H1)O-G-(H2-[L2-E-(B2)K]W)P,   (I) wherein G, H1, H2, D, E, B1, B2, M, K, L1, L2, O, P, Y, and W are defined herein. The present disclosure also relates to methods of preparing and using such multifunctional molecules to identify encoded molecules capable of binding target molecules.

  本公开涉及多功能分子，包括根据式（I）的分子： ([(b1)m-d-l1]y-h1)o-g-(h2-[L2-e-(b2)k]w)p, (i) 其中 G、H1、H2、D、E、B1、B2、M、K、L1、L2、O、P、Y 和 W 在此定义。本公开还涉及制备和使用这种多功能分子的方法，以鉴定能够结合目标分子的编码分子。
• OLIGONUCLEOTIDE DIRECTED AND RECORDED COMBINATORIAL SYNTHESIS OF ENCODED PROBE MOLECULES
  申请人：Watts, Richard Edward

  公开号：EP3472376A1

  公开（公告）日：2019-04-24
• MOLECULES FOR VERIFYING OLIGONUCLEOTIDE DIRECTED COMBINATORIAL SYNTHESIS AND METHODS OF MAKING AND USING THE SAME
  申请人：Haystack Sciences Corporation

  公开号：EP3619340A1

  公开（公告）日：2020-03-11