| 1219611-02-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• CAS: 1219611-02-5
• 化学式: C₂₃H₃₂O₂S
• 分子量: 372.572
• InChiKey: QRJPYPJWXMLFHY-RTBURBONSA-N

反应信息

• 作为反应物：
  描述：

  、 碘甲烷 在 甲醇 、 potassium hydroxide 作用下， 以 乙醇 为溶剂， 生成 (6aR,10aR)-6,6,9-trimethyl-1-(methylthio)-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromene
  参考文献：
  名称：

  Synthesis and structure–activity relationship of substitutions at the C-1 position of Δ9-tetrahydrocannabinol

  摘要：

  A novel series of Delta 9-tetrahydrocannabinol (Delta 9-THC) analogues were synthesized to determine their potential as cannabinoid receptor modulators. Chemistry focused on conversion of the phenol of Delta 9-THC to other functionality through palladium catalyzed reactions with an intermediate triflate 2. Two analogues with sub 100 nM affinity for the CB1 and CB2 receptors were identified. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.12.092
• 作为产物：
  描述：

  、 乙酸酐 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and structure–activity relationship of substitutions at the C-1 position of Δ9-tetrahydrocannabinol

  摘要：

  A novel series of Delta 9-tetrahydrocannabinol (Delta 9-THC) analogues were synthesized to determine their potential as cannabinoid receptor modulators. Chemistry focused on conversion of the phenol of Delta 9-THC to other functionality through palladium catalyzed reactions with an intermediate triflate 2. Two analogues with sub 100 nM affinity for the CB1 and CB2 receptors were identified. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.12.092