2-hydroxybenzylaminomethylphosphonic acid | 879083-87-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-hydroxybenzylaminomethylphosphonic acid
• 英文别名: HBAMPA；[(2-Hydroxyphenyl)methylamino]methylphosphonic acid
• CAS: 879083-87-1
• 化学式: C₈H₁₂NO₄P
• 分子量: 217.161
• InChiKey: HROGVKPENLQXTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  89.8
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  [(2-hydroxyphenyl)methylideneamino]methylphosphonic acid 在 sodium tetrahydroborate 作用下， 生成 2-hydroxybenzylaminomethylphosphonic acid
  参考文献：
  名称：

  New Chelating Ligands with Potential for Pharmaceutical Applications

  摘要：

  2-hydroxybenzylaminomethylphosphonic acid (HBAMPA) has been synthesized from commercially available chemicals and its aqueous coordination chemistry involving Al3 +, Ga3 + and Fe3 + is described. At 25 degrees C and 0.1 M ionic strength KNO3, both Al3 + and Ga3 + formed dinuclear complexes while Fe3 + formed the simple 1:1 complex (FeL) along with a mono-protonated complex (FeLH). HBAMPA formed neutral complexes with these trivalent metal ions, which lead to an early precipitation. The solution mixtures precipitated at pH 6.0 for Al3 +, pH 4.0 for Fe3 +, and pH 3.0 for the Ga3 + ion. The carboxylic acid analogue of HBAMPA, 2-hydroxybenzylalanine (HBA) also has been tested with Al3 + and Fe3 +. It appeared that HBA solubilized the Al3 + ion at pH 7.4. However, the Fe3 +-HBA solution mixture formed a complex of a very minimum solubility and an early pH precipitation prevailed. HBA and HBAMPA are multi-dentate, phenol-containing ligands capable of binding a variety of metal ions with very high stability constants. These stability constants are discussed.

  DOI：

  10.1080/15533170903492861