4-叠氮-2,3,5,6-四氟苯甲酸 | 72826-34-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫杂环戊烷
• 中文名称: 4-叠氮-2,3,5,6-四氟苯甲酸
• 英文名称: 3-Acetamido-2-hydroxytetrahydrothiophene
• 英文别名: N-(2-hydroxythiolan-3-yl)acetamide
• CAS: 72826-34-7
• 化学式: C₆H₁₁NO₂S
• 分子量: 161.22
• InChiKey: BUFPXIOAGYAQEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Phosphorylcholine-containing poly(meth)acrylamide-based copolymers
  申请人：Novartis AG

  公开号：US10676608B2

  公开（公告）日：2020-06-09

  The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymer comprising dangling (i.e., pendant) phosphorylcholine groups and dangling (i.e., pendant) reactive groups or chains each of which comprises one carboxyl group, one thiol group, or one primary or secondary amino group. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.

  本发明涉及一类亲水性聚(甲基)丙烯酰胺基共聚物，该共聚物包含悬垂(即垂挂)磷酰胆碱基团和悬垂(即垂挂)反应基团或链，每个反应基团或链包含一个羧基、一个硫醇基团或一个伯氨基或仲氨基。亲水共聚物对医疗器械或隐形眼镜上的聚阴离子聚合物基底涂层具有较高的亲和力，并且在加热时对含氮聚合物的氮杂环丁烷基团具有反应性。它们特别适用于生产水溶性高支化亲水性聚合物材料和水梯度隐形眼镜。
• PHOSPHORYLCHOLINE-CONTAINING POLY(METH)ACRYLAMIDE-BASED COPOLYMERS
  申请人：Novartis AG

  公开号：US20190023891A1

  公开（公告）日：2019-01-24

  The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymer comprising dangling (i.e., pendant) phosphorylcholine groups and dangling (i.e., pendant) reactive groups or chains each of which comprises one carboxyl group, one thiol group, or one primary or secondary amino group. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.