2-[(4-Fluorophenyl)amino]-6-(2-methoxyethoxy)-9-butyl-9h-purine | 278615-89-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-[(4-Fluorophenyl)amino]-6-(2-methoxyethoxy)-9-butyl-9h-purine
• 英文别名: 9-butyl-N-(4-fluorophenyl)-6-(2-methoxyethoxy)purin-2-amine
• CAS: 278615-89-7
• 化学式: C₁₈H₂₂FN₅O₂
• 分子量: 359.403
• InChiKey: NVJISLYEVSSHEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  74.1
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• US6414147B1
  申请人：——

  公开号：US6414147B1

  公开（公告）日：2002-07-02
• [EN] 2-AMINO-9-ALKYLPURINES: GABA BRAIN RECEPTOR LIGANDS<br/>[FR] 2-AMINO-9-ALKYLPURINES: LIGANDS POUR RECEPTEURS CEREBRAUX GABA
  申请人：NEUROGEN CORP

  公开号：WO2000037471A1

  公开（公告）日：2000-06-29

  Disclosed are compounds of formula (1): or the pharmaceutically acceptable non-toxic salts thereof wherein: W is oxygen or sulphur; X is (un)substituted lower alkyl; or X is (un)substituted aryl or heteroaryl; Y is hydrogen or lower alkyl; Z is lower alkenyl, lower alkynyl, or (un)substituted lower alkyl; T is (un)substituted aryl or heteroaryl. The compounds are highly selective agonists, antagonists, or inverse agonists for GABAa brain receptors, or prodrugs of agonists, antagonists, or inverse agonists for GABAa brain receptors. Thus these compounds are useful in the diagnosis and treatment of anxiety, sleep and seizure disorders. Down's Syndrome, overdose with benzodiazepine drugs, and for the enhancement of memory.