2-(2-aminoethoxy)-9-diethylamino-5H-benzo[a]phenoxazin-5-one | 877932-58-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 2-(2-aminoethoxy)-9-diethylamino-5H-benzo[a]phenoxazin-5-one
• 英文别名: 2-(2-aminoethoxy)-Nile Red；2-(2-Aminoethoxy)-9-(diethylamino)benzo[a]phenoxazin-5-one
• CAS: 877932-58-6
• 化学式: C₂₂H₂₃N₃O₃
• 分子量: 377.443
• InChiKey: YERBAOMMCNVEMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  77.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-(2-aminoethoxy)-9-diethylamino-5H-benzo[a]phenoxazin-5-one 、 碘代乙酸酐 以 二氯甲烷 为溶剂， 反应 0.67h， 生成 2-iodoacetylamidoethoxy-Nile Red
  参考文献：
  名称：

  [EN] LONG WAVELENGTH THIOL-REACTIVE FLUOROPHORES
  [FR] FLUOROPHORES REAGISSANT A THIOL A LONGUEURS D'ONDES ELEVEES

  摘要：

  公开号：

  WO2006025887A3
• 作为产物：
  描述：

  2-(2-phthalimidylethoxy)-Nile Red 在 甲胺 作用下， 以 甲醇 为溶剂， 反应 2.58h， 生成 2-(2-aminoethoxy)-9-diethylamino-5H-benzo[a]phenoxazin-5-one
  参考文献：
  名称：

  [EN] LONG WAVELENGTH THIOL-REACTIVE FLUOROPHORES
  [FR] FLUOROPHORES REAGISSANT A THIOL A LONGUEURS D'ONDES ELEVEES

  摘要：

  公开号：

  WO2006025887A3

文献信息

• Extremely fast triplet formation by charge recombination in a Nile Red/fullerene flexible dyad
  作者：Federica Faroldi、Brunella Bardi、Irene Tosi、Sandra Doria、Jacopo Isopi、Laura Baldini、Mariangela Di Donato、Massimo Marcaccio、Francesco Sansone、Francesca Terenziani

  DOI：10.1039/d1tc01885j

  日期：——

  and ultrafast transient absorption experiments, as well as with electrochemical and spectroelectrochemical techniques. We demonstrate extremely fast and efficient formation of a long-lived excited triplet localized on the fullerene moiety in this system, occurring in about 80 ps in toluene and 220 ps in chloroform. The mechanism of this process is investigated and discussed. The spectroscopic and electrochemical

  通过将尼罗红和富勒烯连接到杯[4]芳烃支架上获得供体/受体二元组。对二元组进行了光谱表征，包括稳态和超快瞬态吸收实验，以及电化学和光谱电化学技术。我们证明了在该系统中定位于富勒烯部分的长寿命激发三重态的形成极其快速和有效，在甲苯中发生约 80 ps，在氯仿中发生约 220 ps。对该过程的机制进行了研究和讨论。光谱和电化学表征表明电子从尼罗红转移到富勒烯，导致形成电荷分离状态。这种状态非常短暂，并且由于电子供体和受体之间的相互作用很小，
• POLYMERIC DERIVATIVE OF MACROLIDE IMMUNOSUPPRESSANT
  申请人：Nippon Kayaku Kabushiki Kaisha

  公开号：EP3378494A1

  公开（公告）日：2018-09-26

  A problem of the present invention is to obtain a preparation which shows markedly enhanced effectiveness and safety by exhibiting high accumulability at diseased areas and having the blood concentration maintained at a constant level without individual differences, and for which the control of the dosage depending on the blood kinetics (blood trough concentration) becomes unnecessary. The invention relates to a polymeric derivative of tacrolimus including a copolymer of a polyethylene glycol segment and a polymeric moiety, in which a carboxy group in a side chain of the copolymer is bonded to an alcoholic hydroxy group of tacrolimus.

  本发明的一个问题是获得一种制剂，该制剂在病变部位表现出高蓄积性，血药浓度保持在一个恒定的水平，没有个体差异，从而明显提高了有效性和安全性，而且不需要根据血液动力学（血槽浓度）来控制剂量。本发明涉及一种他克莫司的聚合物衍生物，包括聚乙二醇段和聚合物分子的共聚物，其中共聚物侧链中的羧基与他克莫司的醇羟基键合。
• LONG WAVELENGTH THIOL-REACTIVE FLUOROPHORES
  申请人：Pitner J. Bruce

  公开号：US20100003763A1

  公开（公告）日：2010-01-07

  Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus.
• Polymeric Derivative Of Macrolide Immunosuppressant
  申请人：Nippon Kayaku Kabushiki Kaisha

  公开号：US20180334540A1

  公开（公告）日：2018-11-22

  A problem of the present invention is to obtain a preparation which shows markedly enhanced effectiveness and safety by exhibiting high accumulability at diseased areas and having the blood concentration maintained at a constant level without individual differences, and for which the control of the dosage depending on the blood kinetics (blood trough concentration) becomes unnecessary. The invention relates to a polymeric derivative of tacrolimus including a copolymer of a polyethylene glycol segment and a polymeric moiety, in which a carboxy group in a side chain of the copolymer is bonded to an alcoholic hydroxy group of tacrolimus.
• US7563891B2
  申请人：——

  公开号：US7563891B2

  公开（公告）日：2009-07-21