dimethyl-(4-propoxy-butyl)-amine | 98958-25-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: dimethyl-(4-propoxy-butyl)-amine
• 英文别名: 1-Dimethylamino-4-propoxy-butan；Dimethyl-(4-propoxy-butyl)-amin；N,N-dimethyl-4-propoxybutan-1-amine
• CAS: 98958-25-9
• 化学式: C₉H₂₁NO
• 分子量: 159.272
• InChiKey: GCFGCZBNPJLOLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  dimethyl-(4-propoxy-butyl)-amine 、 碘甲烷 生成 trimethyl-(4-propoxy-butyl)-ammonium; iodide
  参考文献：
  名称：

  Guermont, Bulletin de la Societe Chimique de France, 1953, p. 386,389

  摘要：

  DOI：
• 作为产物：
  描述：

  丙炔醚 在 1,4-二氧六环 、 乙醇 、 镍 作用下， 生成 dimethyl-(4-propoxy-butyl)-amine
  参考文献：
  名称：

  Guermont; Marszak, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1952, vol. 235, p. 252

  摘要：

  DOI：

文献信息

• Biodegradable lipids for the delivery of active agents
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US11071784B2

  公开（公告）日：2021-07-27

  The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

  本发明涉及一种阳离子脂质，该阳离子脂质的脂质分子（如疏水链）中含有一个或多个可生物降解的基团。 这些阳离子脂质可掺入脂质颗粒中，用于递送核酸等活性剂。 本发明还涉及由中性脂质、能够减少聚集的脂质、本发明的阳离子脂质和可选的固醇组成的脂质颗粒。 脂质微粒可进一步包括治疗剂，如核酸。
• NUCLEIC ACID LIPID PARTICLE FORMULATIONS
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20170233734A1

  公开（公告）日：2017-08-17

  The present invention relates to lipid nanoparticles containing a biodegradable cationic lipid which provide improved delivery of active pharmaceutical ingredients, such as siRNA.
• BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20220175929A1

  公开（公告）日：2022-06-09

  The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.
• US9687448B2
  申请人：——

  公开号：US9687448B2

  公开（公告）日：2017-06-27
• Guermont, Bulletin de la Societe Chimique de France, 1953, p. 386,389
  作者：Guermont

  DOI：——

  日期：——