N-Benzylmonothiophthalimid | 14160-15-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-Benzylmonothiophthalimid
• 英文别名: N-Benzylthiophthalimide；2-benzyl-3-sulfanylideneisoindol-1-one
• CAS: 14160-15-7
• 化学式: C₁₅H₁₁NOS
• 分子量: 253.324
• InChiKey: MMWQKFNXBPPXIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  52.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-Benzylmonothiophthalimid 在 palladium on activated charcoal 、 乙酸乙酯 作用下， 生成 3-苯胺基-2-苄基异吲哚啉-1-酮
  参考文献：
  名称：

  Koermendy, Acta Chimica Academiae Scientiarum Hungaricae, 1958, vol. 17, p. 255,261

  摘要：

  DOI：
• 作为产物：
  描述：

  N-苄基酞酰亚胺 在 phosphorous (V) sulfide 、 苯胺 、 xylene 作用下， 生成 N-Benzylmonothiophthalimid
  参考文献：
  名称：

  Koermendy, Acta Chimica Academiae Scientiarum Hungaricae, 1958, vol. 17, p. 255,261

  摘要：

  DOI：

文献信息

• Synthesis and characterization of FvW2(CO)4L2(SR)2 (L=CO, PPh2Me; R=H, i-Pr, CH2Ph, Ph) type (fulvalene)tungsten dihydrosulfides and dithiolates
  作者：István Kovács、Alan Shaver

  DOI：10.1016/s0022-328x(99)00158-8

  日期：1999.7

  FvW2(CO)4(PPh2Me)2(SR)2 (R=i-Pr, CH2Ph, Ph), upon treatment with RSphthalimide. FvW2(CO)4(PPh2Me)2(SPh)2 was converted into FvW2(CO)4(PPh2Me)2(SH)2 under an atmosphere of H2S. All PPh2Me-substituted dithiolato complexes as well as the bishydrosulfide derivative exist in solution as an equilibrium mixture of d,l- and meso-cis,cis, cis,trans and trans,trans isomers. However, only the cis,cis isomer of the

  的（等人直接，高产率合成4 N）2 [FVW 2（CO）6 ]，其中的Fv =η 5：η 5 -C 10 ħ 8（富瓦烯），从W（CO）3（EtCN）3报道了Li 2 [C 10 H 8 ]和Et 4 NBr。它与硫转移试剂RSphthalimide（R = i -Pr ，CH 2 Ph，Ph）反应，得到相应的二硫代lato配合物FvW 2（CO）6（SR）2。处理硫代巯基配合物，其中R = i-Pr，CH 2 Ph与CS 2经由混合的RSW（CO）3（μ-Fv）（CO）2 WS 2 CSR中间体得到噻吨酸酯衍生物FvW 2（CO）4（S 2 CSR）2。不稳定的双氢硫化氢络合物FvW 2（CO）6（SH）2是通过混合的氢-氢硫化氢中间体FvW 2（CO）6（SH）H从FvW 2（CO）6 H 2和S 8获得的。FVW 2（CO）6 ħ 2还与PPh 2 Me反应，得到配体取代的产物FvW
• Triazolo-4,1-benzoxazepines having CNS activity
  申请人：Shionogi & Co., Ltd.

  公开号：US04476133A1

  公开（公告）日：1984-10-09

  4,1-Benzoxazepines of the following formula are novel central nervous system: ##STR1## wherein R is hydrogen or C.sub.1 to C.sub.5 alkyl; X is hydrogen, halogen, or nitro; Y is phenyl, 2-halophenyl, 4-halophenyl, 2-trifluoromethylphenyl, or pyridyl; and ##STR2## is a group of the formula: ##STR3## (wherein Q is oxygen, sulfur, or hydrazono, with a proviso that, when Y is phenyl or 2-halophenyl and R is hydrogen, Q is neither oxygen nor sulfur; R.sup.1 is hydrogen, halogen, C.sub.1 to C.sub.5 alkyl, C.sub.1 to C.sub.5 alkylthio, 5- or 6-membered heterocycle or C.sub.1 to C.sub.5 alkyl substituted by a substituent selected from the group consisting of halogen, hydroxy, mercapto, C.sub.1 to C.sub.5 alkoxy, C.sub.1 to C.sub.5 alkanoyloxy, C.sub.1 to C.sub.5 alkylthio, C.sub.7 to C.sub.9 aralkyldithio, C.sub.2 to C.sub.10 dialkylamino, C.sub.3 to C.sub.15 dialkylaminoalkoxy, C.sub.3 to C.sub.15 dialkylaminoalkylthio, and 5- or 6-membered heterocycle; R.sup.2 is C.sub.1 to C.sub.5 alkyl; and R.sup.3 is C.sub.1 to C.sub.5 alkyl or C.sub.3 to C.sub.10 dialkylaminoalkyl; with a proviso that when R.sup.1 is C.sub.1 to C.sub.5 alkyl and R is hydrogen, Y is neither phenyl nor 2-halophenyl)

  以下化学式所示的4,1-苯并噁唑啉是新型中枢神经系统药物：##STR1## 其中R为氢或C.sub.1到C.sub.5烷基；X为氢，卤素或硝基；Y为苯基，2-卤苯基，4-卤苯基，2-三氟甲基苯基或吡啶基；而##STR2##是以下公式的基团：##STR3## （其中Q为氧，硫或肼酰基，但当Y为苯基或2-卤苯基且R为氢时，Q既不是氧也不是硫；R.sup.1为氢，卤素，C.sub.1到C.sub.5烷基，C.sub.1到C.sub.5硫代烷基，5或6成员杂环或C.sub.1到C.sub.5烷基，其被从卤素，羟基，硫巴，C.sub.1到C.sub.5烷氧基，C.sub.1到C.sub.5烷基酰氧基，C.sub.1到C.sub.5硫代烷氧基，C.sub.7到C.sub.9芳基硫代烷氧基，C.sub.2到C.sub.10二烷基氨基，C.sub.3到C.sub.15二烷基氨基烷氧基，C.sub.3到C.sub.15二烷基氨基烷硫基或5或6成员杂环所选的取代基所取代；R.sup.2为C.sub.1到C.sub.5烷基；R.sup.3为C.sub.1到C.sub.5烷基或C.sub.3到C.sub.10二烷基氨基烷基；但当R.sup.1为C.sub.1到C.sub.5烷基且R为氢时，Y既不是苯基也不是2-卤苯基。
• 4,1-Benzoxazepines and compositions
  申请人：Shionogi & Co., Ltd.

  公开号：US04374842A1

  公开（公告）日：1983-02-22

  4,1-Benzoxazepines of the following formula are central nervous system drugs: ##STR1## wherein R is hydrogen or C.sub.1 to C.sub.5 alkyl; X is hydrogen, halogen, or nitro; Y is phenyl, 2-halophenyl, 4-halophenyl, 2-trifluoromethylphenyl, or pyridyl; and ##STR2## is a group of the formula: ##STR3## (wherein Q is oxygen, sulfur, or hydrazono, with a proviso that, when Y is phenyl or 2-halophenyl and R is hydrogen, Q is neither oxygen nor sulfur; R.sup.1 is hydrogen, halogen, C.sub.1 to C.sub.5 alkyl, C.sub.1 to C.sub.5 alkylthio, 5- or 6-membered heterocycle or C.sub.1 to C.sub.5 alkyl substituted by a substituent selected from the group consisting of halogen, hydroxy, mercapto, C.sub.1 to C.sub.5 alkoxy, C.sub.1 to C.sub.5 alkanoyloxy, C.sub.1 to C.sub.5 alkylthio, C.sub.7 to C.sub.9 aralkyldithio, C.sub.2 to C.sub.10 dialkylamino, C.sub.3 to C.sub.15 dialkylaminoalkoxy, C.sub.3 to C.sub.15 dialkylaminoalkylthio, and 5- or 6-membered heterocycle; R.sup.2 is C.sub.1 to C.sub.5 alkyl; and R.sup.3 is C.sub.1 to C.sub.5 alkyl or C.sub.3 to C.sub.10 dialkylaminoalkyl; with a proviso that when R.sup.1 is C.sub.1 to C.sub.5 alkyl and R is hydrogen, Y is neither phenyl nor 2-halophenyl).

  以下公式的4,1-苯并噁唑环化合物是中枢神经系统药物： ##STR1## 其中R为氢或C.sub.1到C.sub.5烷基；X为氢，卤素或硝基；Y为苯基，2-卤苯基，4-卤苯基，2-三氟甲基苯基或吡啶基；以及##STR2## 是以下公式的基团： ##STR3## （其中Q为氧，硫或肼酰基，但当Y为苯基或2-卤苯基且R为氢时，Q既不是氧也不是硫；R.sup.1为氢，卤素，C.sub.1到C.sub.5烷基，C.sub.1到C.sub.5烷基硫醚，5-或6-成员杂环或C.sub.1到C.sub.5烷基被从卤素，羟基，巯基，C.sub.1到C.sub.5烷氧基，C.sub.1到C.sub.5烷基酰氧基，C.sub.1到C.sub.5烷基硫醚，C.sub.7到C.sub.9芳基硫代基，C.sub.2到C.sub.10二烷基氨基，C.sub.3到C.sub.15二烷基氨基烷氧基，C.sub.3到C.sub.15二烷基氨基烷硫基，和5-或6-成员杂环的取代基中选择；R.sup.2为C.sub.1到C.sub.5烷基；R.sup.3为C.sub.1到C.sub.5烷基或C.sub.3到C.sub.10二烷基氨基烷基；但当R.sup.1为C.sub.1到C.sub.5烷基且R为氢时，Y既不是苯基也不是2-卤苯基。
• A Facile and Efficient One-Pot Procedure for the Synthesis of Novel 2-Substituted 3-Thioxoisoindolin-1-one Derivatives
  作者：Mehdi Adib、Mohammad Mahdavi、Fatemeh Gholami、Ali Moazzam、Saeed Bahadorikhalili、Samanesadat Hosseini、Bagher Larijani

  DOI：10.1055/a-1912-2293

  日期：2022.10

  is reported for the synthesis of novel 2-substituted 3-thioxoisoindolin-1-one derivatives. The method is based on the solvent-free reaction of 2-carboxybenzaldehyde with aliphatic amines and sulfur at 100 °C. This reaction is intensely significant, especially in pharmacy applications, due to the facile synthesis of asymmetric thioxoisoindolin-1-one derivatives with phthalimide backbones.

  本文报道了一种新的高效合成新型 2-取代 3-thioxoisoindolin-1-one 衍生物的方法。该方法基于 2-羧基苯甲醛与脂肪胺和硫在 100 °C 下的无溶剂反应。由于具有邻苯二甲酰亚胺骨架的不对称硫代异吲哚啉-1-酮衍生物的简便合成，该反应非常重要，特别是在药学应用中。
• US4374842A
  申请人：——

  公开号：US4374842A

  公开（公告）日：1983-02-22