Trifluoromethylstilbene | 928030-90-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: Trifluoromethylstilbene
• 英文别名: 1-(2-phenylethenyl)-2-(trifluoromethyl)benzene
• CAS: 928030-90-4
• 化学式: C₁₅H₁₁F₃
• 分子量: 248.248
• InChiKey: GSUAAHFCMHSJIL-UHFFFAOYSA-N

物化性质

• 沸点：
  291.0±35.0 °C(Predicted)
• 密度：
  1.204±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Trifluoromethylstilbene 在 9-硼双环[3.3.1]壬烷 、 亚硝基叔丁烷 作用下， 以 四氢呋喃 为溶剂， 反应 1.83h， 以69%的产率得到(E)-2-trifluoromethylstilbene
  参考文献：
  名称：

  通过可逆的硼氢化反应对苯乙烯和苯乙烯类化合物进行电子选择性异构化

  摘要：

  E和Z的Stilbenes和Stilbenoids的混合物进行氢硼化后，进行消除反应，得到具有高立体选择性的E异构体。该反应容许具有不同立体电子性质的芳族取代基，发生在一个罐中，并且仅需要可商购的试剂。给出了白藜芦醇（一种生物活性抗氧化剂）的合成中的异构化反应的说明。

  DOI：

  10.1016/j.tetlet.2011.09.046
• 作为产物：
  描述：

  苯乙烯 、 1-氯-2-(三氟甲基)苯 在 potassium carbonate 作用下， 以 乙醇 、 水 为溶剂， 反应 15.0h， 以95%的产率得到Trifluoromethylstilbene
  参考文献：
  名称：

  Palladium supported on zinc oxide nanoparticles: Synthesis, characterization, and application as heterogeneous catalyst for Mizoroki–Heck and Sonogashira reactions under ligand-free and air atmosphere conditions

  摘要：

  In this paper, a novel Palladium (Pd) supported on ZnO nanoparticles was readily synthesized and characterized by using X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and BET specific surface area measurement. The total amount of palladium particles on ZnO was determined by induced coupled plasma (ICP) analysis and atomic absorption spectroscopy (MS) which is 9.8 wt%. Percentage of accessible Pd as active catalyst is also estimated to 2.72% based on the thermogravimetric (TG) analysis. Nano Pd/ZnO was found as a new, novel, and excellent heterogeneous catalyst for ligand-free C-C bond formation through the Mizoroki-Heck and Sonogashira reactions under air atmosphere without the use of any Ar or N-2 flow. The catalyst can be recovered and recycled several times without marked loss of activity. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.apcata.2014.02.002

文献信息

• Efficient C--C cross-coupling reactions by (isatin)-Schiff base functionalized magnetic nanoparticle-supported Cu(II) acetate as a magnetically recoverable catalyst
  作者：Seyedeh Simin MIRI、Mehdi KHOOBI、Fatemeh ASHOURI、Farnaz JAFARPOUR、Parviz RASHIDI RANJBAR、Abbas SHAFIEE

  DOI：10.3906/kim-1506-32

  日期：——

  Copper catalysts were simply fabricated through surface modification of superparamagnetic iron nanoparticles with indoline-2,3-dione(isatin)-Schiff-base and interaction with Cu from low-cost commercially available starting materials. Catalysts were characterized using atomic absorption spectrophotometry, Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, vibrating sample magnetometry, UV/Vis spectroscopy, scanning electron microscopy, and transmission electron microscopy. These catalysts showed high efficiency for phosphine-free Mizoroki--Heck and Suzuki--Miyaura cross-coupling reactions with good diversity and generality. The catalysts could be easily recovered and reused several times without a significant loss in their catalytic activity and stability.

  通过表面修饰超顺磁性铁纳米粒子与异吲哚-2,3-二酮（吲哚醌）席夫碱，并与廉价易得的原料中的铜发生相互作用，简单制备了铜催化剂。通过原子吸收分光光度法、傅里叶变换红外光谱、X射线衍射、热重分析、振动样品磁强计、紫外/可见光谱、扫描电子显微镜和透射电子显微镜对催化剂进行了表征。这些催化剂对无磷Mizoroki-Heck和Suzuki-Miyaura交叉偶联反应表现出高效率和良好的多样性和通用性。催化剂可以轻松回收并重复使用多次，不会明显损失其催化活性和稳定性。
• Substituted CIS- and trans-stilbenes as therapeutic agents
  申请人：Vander Jagt David L.

  公开号：US20070249647A1

  公开（公告）日：2007-10-25

  The present invention relates to method(s) of treating a subject afflicted with cancer or a precancerous condition, an inflammatory disease or condition, and/or stroke or other ischemic disease or condition, the method comprising administering to the subject or patient in need a composition comprising a therapeutically effective amount of a substituted cis or trans-stilbene.

  本发明涉及治疗患有癌症或癌前病变、炎症性疾病或病情以及中风或其他缺血性疾病或病情的方法，该方法包括向需要的受试者或患者施用含有一定治疗有效量的取代的顺式或反式-芪的组合物。
• Pd(II) and Rh(I) Catalytic Precursors for Arene Alkenylation: Comparative Evaluation of Reactivity and Mechanism Based on Experimental and Computational Studies
  作者：Marc T. Bennett、Xiaofan Jia、Charles B. Musgrave、Weihao Zhu、William A. Goddard、T. Brent Gunnoe

  DOI：10.1021/jacs.3c04295

  日期：2023.7.19

  does not correlate with arene electronics. In contrast, with Pd catalysis, electron-rich arenes react more rapidly than benzene, while electron-deficient arenes react less rapidly than benzene. These experimental findings, in combination with computational results, are consistent with the arene C–H activation step for Pd catalysis involving significant η1-arenium character due to Pd-mediated electrophilic

  我们结合实验和计算研究来比较和理解使用 Pd(II) 和 Rh(I) 前体 Pd(OAc) 2和 [(η 2 -C 2 H 4 ) 2 Rh(μ-OAc)] 2的催化芳烃烯基化反应与芳烃、烯烃和羧酸铜 (II) 在高温 (>120 °C) 下反应。在特定条件下，先前的计算和实验工作已经确定了异三金属环状PdCu 2 (η 2 -C 2 H 4 ) 3 (μ-OPiv) 6和[(η 2 -C 2 H 4 ) 2 Rh(μ-OPiv) 2 ] 2 (μ-Cu) (OPiv = 新戊酸盐) 物种可能作为这些过程的活性催化剂。对催化剂形态的进一步研究表明，含有一个 Rh 或 Pd 原子的含 Cu(II) 配合物与含有两个 Rh 或 Pd 原子的配合物之间存在复杂的平衡。在 120 °C 时，Rh 催化产生苯乙烯的速度是 Pd 的 20 倍以上。此外，在 120 °C 时，Rh 对苯乙烯形成的选择性约为
• FORMULATION AND PROCESS FOR MODULATING WOUND HEALING
  申请人：Biomendics LLC

  公开号：EP3280402A2

  公开（公告）日：2018-02-14
• SUBSTITUTED CIS- AND TRANS-STILBENES AS THERAPEUTIC AGENTS
  申请人：STC. UNM

  公开号：US20130178536A1

  公开（公告）日：2013-07-11

  The present invention relates to method(s) of treating a subject afflicted with cancer or a precancerous condition, an inflammatory disease or condition, and/or stroke or other ischemic disease or condition, the method comprising administering to the subject or patient in need a composition comprising a therapeutically effective amount of a substituted cis or trans-stilbene. A method of treating or reducing the likelihood of Alzheimer's disease in a patient is an additional embodiment of the present invention.