2'-O-(palmitoyl)uridine | 1034292-52-8

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 2'-O-(palmitoyl)uridine
• 英文别名: [(2R,3R,4R,5R)-2-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl] hexadecanoate
• CAS: 1034292-52-8
• 化学式: C₂₅H₄₂N₂O₇
• 分子量: 482.618
• InChiKey: MVPRIHBHXRQGKD-OTUUDDROSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  34
• 可旋转键数：
  18
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  125
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  在 氟化铵 作用下， 以 甲醇 为溶剂， 生成 2'-O-(palmitoyl)uridine 、 3'-O-(palmitoyl)uridine
  参考文献：
  名称：

  2'-固定脂锚核苷的合成及其在磷脂膜中的行为

  摘要：

  已经合成了各种在 2' 位带有一个或两个亲脂基团的新核苷。亲脂性取代基连接到 2'-羟基、2'-氨基或 2'-硫代官能团。这些亲脂性核苷锚定在用作磷脂膜模型的大型单层 POPC 囊泡中。通过核磁共振技术研究了这些分子插入到膜中的情况。为了进行比较，还研究了在 2'-、3'-或 5'-位置具有两个或三个亲脂基团的核苷。（© Wiley-VCH Verlag GmbH & Co. KGaA，69451 Weinheim，德国，2008 年）

  DOI：

  10.1002/ejoc.200701064

文献信息

• [EN] ACYL RIBONUCLEOSIDES AND ACYL DEOXYRIBONUCLEOSIDES<br/>[FR] RIBONUCLEOSIDES D'ACYLE ET DESOXYRIBONUCLEOSIDES D'ACYLE
  申请人：COGNIS IP MAN GMBH

  公开号：WO2005049633A1

  公开（公告）日：2005-06-02

  The present invention is concerned with acyl ribonucleosides and with acyl deoxyribonucleosides. It is furthermore concerned with an enzymatic process for the manufacture of acyl ribonucleosides and of acyl deoxyribonucleosides. It is furthermore concerned with the use of acyl ribonucleosides and of acyl deoxyribonucleosides for cosmetic and for pharmaceutical purposes and with their use as a food supplement for humans or animals. It is furthermore concerned with compositions containing acyl ribonucleosides and acyl deoxyribonucleosides, whereby these compositions are suitable for cosmetic or for pharmaceutical purposes or as food supplement.

  本发明涉及酰基核糖核苷和酰基脱氧核糖核苷。此外，本发明还涉及一种用于制造酰基核糖核苷和酰基脱氧核糖核苷的酶法过程。此外，本发明还涉及酰基核糖核苷和酰基脱氧核糖核苷在化妆品和药品中的用途，以及它们作为人类或动物的食品补充剂的用途。此外，本发明还涉及含有酰基核糖核苷和酰基脱氧核糖核苷的组合物，这些组合物适用于化妆品或药品或作为食品补充剂。
• ACYL RIBONUCLEOSIDES AND ACYL DEOXYRIBONUCLEOSIDES
  申请人：Cognis IP Management GmbH

  公开号：EP1680435A1

  公开（公告）日：2006-07-19
• Acyl ribonucleosides and acyl deoxyribonucleosides, compositions of, and methods of making same
  申请人：Kempers Peter

  公开号：US20070160554A1

  公开（公告）日：2007-07-12

  The present invention is concerned with acyl ribonucleosides and with acyl deoxyribonucleosides. It is furthermore concerned with an enzymatic process for the manufacture of acyl ribonucleosides and of acyl deoxyribonucleosides. It is furthermore concerned with the use of acyl ribonucleosides and of acyl deoxyribonucleosides for cosmetic and for pharmaceutical purposes and with their use as a food supplement for humans or animals. It is furthermore concerned with compositions containing acyl ribonucleosides and acyl deoxyribonucleosides, whereby these compositions are suitable for cosmetic or for pharmaceutical purposes or as food supplement.