(1-Tert-butyl-3-methylazetidin-3-yl)methanol | 1353650-43-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (1-Tert-butyl-3-methylazetidin-3-yl)methanol
• 英文别名: (1-tert-butyl-3-methylazetidin-3-yl)methanol
• CAS: 1353650-43-7
• 化学式: C₉H₁₉NO
• 分子量: 157.256
• InChiKey: NQDOCQYVVMMEGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-bromo-1-t-butyl-3-methylazetidine 在 lithium aluminium tetrahydride 、 水 、 potassium hydroxide 作用下， 以 乙醚 、 乙醇 为溶剂， 反应 123.0h， 生成 (1-Tert-butyl-3-methylazetidin-3-yl)methanol
  参考文献：
  名称：

  Synthesis of 3-functionalized 3-methylazetidines

  摘要：

  1-t-Butyl- and 1-(4-methylbenzyl)-3-bromo-3-methylazetidines were prepared from the corresponding N-(2,3-dibromo-2-methylpropylidene)alkylamines and their propensity to undergo nucleophilic substitution at the 3-position by different nucleophiles was assessed, providing a convenient access to novel 3-alkoxy-, 3-aryloxy-, 3-hydroxy-, 3-cyano-, 3-carboxy-, 3-(aminomethyl)- and 3-(hydroxymethyl)azetidines. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.10.097

文献信息

• CARM1 INHIBITORS AND USES THEREOF
  申请人：Epizyme, Inc.

  公开号：US20170305922A1

  公开（公告）日：2017-10-26

  Provided herein are compounds of Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein R1, R2a, R2b, R3 and Ring B are as defined herein, and Ring A is a group of Formula (A-i), (A-ii), or (A-iii): wherein R, R, R, R, and R are as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.
• PREPARATION AND APPLICATION OF AROMATIC COMPOUND HAVING IMMUNOREGULATORY FUNCTION
  申请人：SHANGHAI ENNOVABIO PHARMACEUTICALS CO., LTD.

  公开号：US20210347785A1

  公开（公告）日：2021-11-11

  Provided are an aromatic compound having immunoregulatory effect, a preparation method thereof, and a use of the same in regulating immune responses or inhibiting PD-1/PD-L1.
• Synthesis of 3-functionalized 3-methylazetidines
  作者：Sonja Stanković、Matthias D’hooghe、Kourosch Abbaspour Tehrani、Norbert De Kimpe

  DOI：10.1016/j.tetlet.2011.10.097

  日期：2012.1

  1-t-Butyl- and 1-(4-methylbenzyl)-3-bromo-3-methylazetidines were prepared from the corresponding N-(2,3-dibromo-2-methylpropylidene)alkylamines and their propensity to undergo nucleophilic substitution at the 3-position by different nucleophiles was assessed, providing a convenient access to novel 3-alkoxy-, 3-aryloxy-, 3-hydroxy-, 3-cyano-, 3-carboxy-, 3-(aminomethyl)- and 3-(hydroxymethyl)azetidines. (C) 2011 Elsevier Ltd. All rights reserved.