N¹-isopropyl-1-phenyl-ethanediyldiamine | 42164-55-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N¹-isopropyl-1-phenyl-ethanediyldiamine
• 英文别名: N¹-Isopropyl-1-phenyl-aethandiyldiamin；N¹-Isopropyl-1-phenyl-aethylendiamin；2-Amino-1-isopropylamino-1-phenyl-aethan；1-phenyl-N-propan-2-ylethane-1,2-diamine
• CAS: 42164-55-6
• 化学式: C₁₁H₁₈N₂
• 分子量: 178.277
• InChiKey: JVNSMNSURRNHGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N¹-isopropyl-1-phenyl-ethanediyldiamine 在 盐酸 作用下， 反应 0.5h， 生成 2-Ethylsulfanyl-1-isopropyl-5-phenyl-4,5-dihydro-1H-imidazole; hydrochloride
  参考文献：
  名称：

  Brienne; Jacques; Gayral, European Journal of Medicinal Chemistry, 1981, vol. 16, # 4, p. 363 - 366

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(cyano-phenyl-methyl)-N-isopropyl-acetamide 在 氢氧化钾 、 sodium hydroxide 、 乙醇 、 镍 、 苯甲醇 作用下， 生成 N¹-isopropyl-1-phenyl-ethanediyldiamine
  参考文献：
  名称：

  Funke; Kornmann, Bulletin de la Societe Chimique de France, 1949, p. 241,242

  摘要：

  DOI：

文献信息

• PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL AGENTS
  申请人：Gilead Sciences, Inc.

  公开号：US20130164280A1

  公开（公告）日：2013-06-27

  The invention provides compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections. The compounds and compositions are useful for treating Pneumovirinae virus infection including Human respiratory syncytial virus infections.

  该发明提供了用于治疗病毒感染的化合物、药物可接受的盐和酯以及它们的组合物。这些化合物和组合物对于治疗包括人类呼吸道合胞病毒感染在内的肺病毒亚科病毒感染是有用的。
• PHENYLPYRAZOLE DERIVATIVES AS POTENT ROCK1 AND ROCK2 INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：US20140243338A1

  公开（公告）日：2014-08-28

  The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

  本发明提供了式(I)的化合物：或其立体异构体、互变异构体或药学上可接受的盐，其中所有变量如本文所定义。这些化合物是选择性ROCK抑制剂。本发明还涉及包含这些化合物的药物组合物以及使用这些药物组合物治疗心血管、平滑肌、肿瘤学、神经病理学、自身免疫、纤维化和/或炎症性疾病的方法。
• MODIFIED BLOCK COPOLYMER, METHOD FOR PRODUCING MODIFIED BLOCK COPOLYMER, AND RESIN COMPOSITION
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP3623398A1

  公开（公告）日：2020-03-18

  A modified block copolymer according to the present invention is a modified block copolymer comprising a polymer block comprising a vinyl aromatic compound as a main constituent (A), a polymer block comprising a conjugate diene compound as a main constituent (B), and an atomic group having NHx (x = 0 to 2) (C). In the modified block copolymer, the polymer block comprising a conjugate diene compound as a main constituent (B) is a hydrogenated product, the atomic group having NHx (x = 0 to 2) (C) is contained in a side chain, and a compound forming the atomic group having NHx (x = 0 to 2) (C) satisfies the following condition: Condition: when the compound forming the atomic group having NHx (x = 0 to 2) (C) is reacted with a maleic anhydride-modified group in a maleic anhydride-modified block copolymer, a MFR value at 230°C under a load of 2.16 kg of the modified block copolymer after the reaction is 0.1 times or more a MFR value at 230°C under a load of 2.16 kg of the maleic anhydride-modified block copolymer before the reaction.

  根据本发明，改性嵌段共聚物是一种改性嵌段共聚物，包括以乙烯基芳香族化合物为主要成分的聚合物嵌段（A）、以共轭二烯化合物为主要成分的聚合物嵌段（B）和具有 NHx（x = 0 至 2）的原子团（C）。在改性嵌段聚合物中，由共轭二烯化合物作为主要成分（B）的聚合物嵌段是氢化产物，具有 NHx（x = 0 至 2）（C）的原子团包含在侧链中，形成具有 NHx（x = 0 至 2）（C）的原子团的化合物满足以下条件： 条件：当形成具有 NHx（x = 0 至 2）(C)的原子团的化合物与马来酸酐改性嵌段共聚物中的马来酸酐改性基团反应时，反应后在 230℃、负载 2.16 千克改性嵌段共聚物时的 MFR 值是反应前在 230℃、负载 2.16 千克马来酸酐改性嵌段共聚物时的 MFR 值的 0.1 倍或以上。
• Modified block copolymer, method for producing modified block copolymer, and resin composition
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：US11124593B2

  公开（公告）日：2021-09-21

  A modified block copolymer according to the present invention is a modified block copolymer comprising a polymer block comprising a vinyl aromatic compound as a main constituent (A), a polymer block comprising a conjugate diene compound as a main constituent (B), and an atomic group having NHx (x=0 to 2) (C). In the modified block copolymer, the polymer block comprising a conjugate diene compound as a main constituent (B) is a hydrogenated product, the atomic group having NHx (x=0 to 2) (C) is contained in a side chain, and a compound forming the atomic group having NHx (x=0 to 2) (C).

  根据本发明，改性嵌段共聚物是一种改性嵌段共聚物，包括以乙烯基芳香族化合物为主要成分的聚合物嵌段（A）、以共轭二烯化合物为主要成分的聚合物嵌段（B）和具有 NHx（x=0 至 2）的原子团（C）。在改性嵌段共聚物中，由共轭二烯化合物作为主要成分（B）的聚合物嵌段是氢化产物，具有 NHx（x=0 至 2）（C）的原子团包含在侧链中，以及形成具有 NHx（x=0 至 2）（C）的原子团的化合物。
• Modified Block Copolymer, Method for Producing Modified Block Copolymer, and Resin Composition
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：US20200199282A1

  公开（公告）日：2020-06-25

  A modified block copolymer according to the present invention is a modified block copolymer comprising a polymer block comprising a vinyl aromatic compound as a main constituent (A), a polymer block comprising a conjugate diene compound as a main constituent (B), and an atomic group having NHx (x=0 to 2) (C). In the modified block copolymer, the polymer block comprising a conjugate diene compound as a main constituent (B) is a hydrogenated product, the atomic group having NHx (x=0 to 2) (C) is contained in a side chain, and a compound forming the atomic group having NHx (x=0 to 2) (C).