2,4-bis(pyridin-2-ylmethyl)benzene-1,3,5-triol | 1233132-26-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2,4-bis(pyridin-2-ylmethyl)benzene-1,3,5-triol
• 英文别名: 2,4-Bis(pyridin-2-ylmethyl)benzene-1,3,5-triol
• CAS: 1233132-26-7
• 化学式: C₁₈H₁₆N₂O₃
• 分子量: 308.337
• InChiKey: CPPFWADHKKFEFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  86.5
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,4-bis(pyridin-2-ylmethyl)benzene-1,3,5-triol 、 方酸 以 甲苯 、 正丁醇 为溶剂， 反应 20.0h， 以78%的产率得到
  参考文献：
  名称：

  Squaraine-based colorimetric and fluorescent sensors for Cu2+-specific detection and fluorescence imaging in living cells

  摘要：

  New squaraine-based chemosensors SQ1 and SQ2 functionalized with 2-picolyl units were first synthesized and used as highly selective and sensitive calorimetric and fluorometric dual-channel sensors for Cu2+-specific recognition in aqueous systems. Among a series of individual metal ions, only Cu2+ could result in dramatic color changes. We also evaluated their capability of biological applications and found that SQ2 could be successfully employed as a Cu2+-selective probe in the fluorescence imaging of living cells. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.03.070
• 作为产物：
  描述：

  间苯三酚 、 2-氯甲基吡啶盐酸盐 在 potassium iodide 、 碳酸氢钠 作用下， 以 甲苯 、 甲醇 、 二氯甲烷 为溶剂， 反应 24.0h， 以19%的产率得到2,4-bis(pyridin-2-ylmethyl)benzene-1,3,5-triol
  参考文献：
  名称：

  Squaraine-based colorimetric and fluorescent sensors for Cu2+-specific detection and fluorescence imaging in living cells

  摘要：

  New squaraine-based chemosensors SQ1 and SQ2 functionalized with 2-picolyl units were first synthesized and used as highly selective and sensitive calorimetric and fluorometric dual-channel sensors for Cu2+-specific recognition in aqueous systems. Among a series of individual metal ions, only Cu2+ could result in dramatic color changes. We also evaluated their capability of biological applications and found that SQ2 could be successfully employed as a Cu2+-selective probe in the fluorescence imaging of living cells. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.03.070

文献信息

• Squaraine-based colorimetric and fluorescent sensors for Cu2+-specific detection and fluorescence imaging in living cells
  作者：Weida Wang、Afu Fu、Jingsong You、Ge Gao、Jingbo Lan、Lijuan Chen

  DOI：10.1016/j.tet.2010.03.070

  日期：2010.5

  New squaraine-based chemosensors SQ1 and SQ2 functionalized with 2-picolyl units were first synthesized and used as highly selective and sensitive calorimetric and fluorometric dual-channel sensors for Cu2+-specific recognition in aqueous systems. Among a series of individual metal ions, only Cu2+ could result in dramatic color changes. We also evaluated their capability of biological applications and found that SQ2 could be successfully employed as a Cu2+-selective probe in the fluorescence imaging of living cells. (C) 2010 Elsevier Ltd. All rights reserved.