[EN] METHODS IN CELL CULTURES, AND RELATED INVENTIONS, EMPLOYING CERTAIN ADDITIVES<br/>[FR] PROCÉDÉS EN CULTURES CELLULAIRES, ET INVENTIONS APPARENTÉES, UTILISANT CERTAINS ADDITIFS
                        
                            
                                申请人:BASF SE
                            
                            
                                公开号:WO2011018472A2
                            
                            
                                公开(公告)日:2011-02-17
                            
                            A method for the manufacture of products by biotechnological methods in bacterial cell culture is disclosed as well as products obtained, the use of certain additives to the media used in the manufacture of said products in bacterial cell culture media, and the use of said additives in reducing the detrimental effects of radicals in the manufacture of the products, as well as aspects related to these invention embodiments. The manufacturing process or method comprises adding one or more radical scavenging and/or antioxidative additive preferably selected from the group consisting of sterically hindered nitroxyls, sterically hindered hydroxylamines, sterically hindered hydroxylamine salt compounds, sterically hindered amino compounds and sterically hindered N-hydrocarbyloxyamines, benzofuranone compounds, as obligatory component(s) to the medium used during biosynthesis.