9-Hexyl-6-hydroxy-9H-purin | 7498-14-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-Hexyl-6-hydroxy-9H-purin
• 英文别名: 9-hexyl-1,9-dihydro-purin-6-one；9-hexyl-1H-purin-6-one
• CAS: 7498-14-8
• 化学式: C₁₁H₁₆N₄O
• 分子量: 220.274
• InChiKey: QNGGZNGZWYIWJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  59.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• COMPOSITIONS AND METHODS FOR ADOPTIVE CELL THERAPY FOR CANCER
  申请人：MEMORIAL SLOAN KETTERING CANCER CENTER

  公开号：US20200157518A1

  公开（公告）日：2020-05-21

  Provided herein are compositions and methods for adoptive cell therapy comprising engineered immune cells that express a tumor antigen-targeted chimeric antigen receptor and a prodrug converting enzyme.
• 3'3'-CYCLIC DINUCLEOTIDE ANALOGUE COMPRISING A CYCLOPENTANYL MODIFIED NUCLEOTIDE AS STING MODULATOR
  申请人：INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I

  公开号：US20220160746A1

  公开（公告）日：2022-05-26

  The present disclosure relates to 3′3′-cyclic dinucleotides having a carbocyclic nucleotide and derivatives that can modulate the activity of the STING adaptor protein.