1-methyl-[1,5]diazocane | 4318-36-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-methyl-[1,5]diazocane
• 英文别名: 1-methyl-octahydro-[1,5]diazocine；1-Methyl-octahydro-[1,5]diazocin；1-Methyl-octahydro-1,5-diazocin；1-Methyl-1,5-diaza-cyclooctan；1-Methyl-1,5-diazacyclooctan；N-Methyl-1,5-diazacyclooctan；1-Methyl-1,5-diazocane
• CAS: 4318-36-9
• 化学式: C₇H₁₆N₂
• 分子量: 128.217
• InChiKey: FBMOOJFGIWOUJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3,3'-甲基亚胺-二-丙腈 在 氨 、 镍 作用下， 90.0~100.0 ℃ 、9.81 MPa 条件下， 生成 1-methyl-[1,5]diazocane 、 N,N-双(3-氨丙基)甲胺
  参考文献：
  名称：

  Nasarow; Schwechgeimer, Zhurnal Obshchei Khimii, 1954, vol. 24, p. 157,160,161;engl.Ausg.S.157,159,161

  摘要：

  DOI：

文献信息

• Macrocyclic Spiro Pyrimidine Derivatives
  申请人：Liu Huaqing

  公开号：US20090233904A1

  公开（公告）日：2009-09-17

  Macrocyclic spiro pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions, and disorders using such compounds and compositions are described herein.

  本文描述了大环螺环嘧啶化合物、包含这种化合物的组合物、制备这些化合物的方法，以及利用这种化合物和组合物治疗和预防疾病、病况和障碍的方法。
• SILICONE COMPOUND HAVING A RADICAL-POLYMERIZABLE GROUP AND A METHOD FOR THE PREPARATION THEREOF
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US20150087853A1

  公开（公告）日：2015-03-26

  A purpose of the present invention is to provide a polymerizable group-containing silicone compound which is liquid at room temperature, has good handling properties and compatibility with other polymerizable monomers. The present invention provides a silicone compound represented by the general formula (1) which has a structure represented by the following formula (2) or (3): wherein R c is an alkyl group having 1 to 10 carbon atoms and Z is a radical-polymerizable group; wherein p 1 and p 2 are, independently of each other, positive integers such that a total number of p 1 and p 2 is 3 to 10, and Z is a radical-polymerizable group; and has a silicone structure bonded to the aforesaid formula (2) or (3) via a substituted or unsubstituted divalent hydrocarbon group having 1 to 10 carbon atoms. The present invention further provides a method for preparation the aforesaid silicone compound.

  本发明的目的是提供一种聚合物化基团含硅化合物，该化合物在室温下为液体，具有良好的操控性能和与其他可聚合单体的相容性。本发明提供了一种由一般式(1)表示的硅氧烷化合物，其具有以下式(2)或(3)表示的结构：其中Rc是具有1至10个碳原子的烷基基团，Z是一个基团-可聚合基团；其中p1和p2是彼此独立的正整数，使得p1和p2的总数为3至10，Z是一个基团-可聚合基团；并且具有通过具有1至10个碳原子的取代或未取代的二价碳氢基团与上述式(2)或(3)结合的硅氧烷结构。本发明还提供了制备上述硅氧烷化合物的方法。
• MACROCYCLIC PYRIMIDINE DERIVATIVES
  申请人：Liu Huaqing

  公开号：US20090253678A1

  公开（公告）日：2009-10-08

  Macrocyclic pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions, and disorders using such compounds and compositions are described herein.

  本文描述了大环嘧啶化合物、包含此类化合物的组合物、制备此类化合物的方法以及使用此类化合物和组合物治疗和预防疾病、病症和障碍的方法。
• Compositions of novel opioid compounds and method of use thereof
  申请人：Jan Shyi-Tai

  公开号：US20070043028A1

  公开（公告）日：2007-02-22

  Diarylmethylpiperazine compounds are described, which are useful as mu and/or delta receptor opioid compounds, without central side effects. Pharmaceutical compositions containing such compounds are variously useful for peripheral or non-centrally mediated indications, including peripherally mediated and neuropathic pain, urogenital tract disorders, overactive bladder, urinary incontinence, sexual disorders, premature ejaculation, cough, lung edema, cardiac disorders, cardioprotection, gastrointestinal disorders, diarrhea, irritable bowl syndrome, functional distention, immuno-modulation and anti-tumor activity.

  本文描述了二芳基甲基哌嗪类化合物，其可用作μ和/或δ受体阿片样化合物，而无中枢副作用。含有这种化合物的制药组合物在各种外周或非中枢介导的适应症中有用，包括外周介导和神经病理性疼痛，泌尿道障碍，过度活动膀胱，尿失禁，性功能障碍，早泄，咳嗽，肺水肿，心脏疾病，心脏保护，胃肠疾病，腹泻，肠易激综合征，功能性胀气，免疫调节和抗肿瘤活性。
• [EN] 2,6-DICHLOROPHENYL ESTER COMPOUNDS AND USE THEREOF<br/>[FR] COMPOSÉS DE 2,6-DICHLOROPHÉNYLESTER ET LEUR UTILISATION
  申请人：FUSION PHARMACEUTICALS INC

  公开号：WO2022251612A1

  公开（公告）日：2022-12-01

  The present disclosure relates to 2,6-dichlorophenylester compounds. Also disclosed are methods for using the same for the preparation of certain conjugates.

  本公开涉及2,6-二氯苯酯化合物。还公开了使用它们制备某些共轭物的方法。