| 874291-51-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 亚磺酸及其衍生物
• CAS: 874291-51-7
• 化学式: C₁₀H₂₁NOS
• 分子量: 203.349
• InChiKey: BPMCPPXULCUUSE-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.96
• 重原子数：
  13.0
• 可旋转键数：
  3.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  29.43
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  、 diethylphosphine oxide 在 diethylzinc 作用下， 以 甲苯 为溶剂， 生成 (S)-N-((R)-2-(diethylphosphoryl)-4-methylpentan-2-yl)-2-methylpropane-2-sulfinamide 、 (S)-N-((S)-2-(diethylphosphoryl)-4-methylpentan-2-yl)-2-methylpropane-2-sulfinamide
  参考文献：
  名称：

  Zinc-Mediated Asymmetric Additions of Dialkylphosphine Oxides to α,β-Unsaturated Ketones and N-Sulfinylimines

  摘要：

  A catalyst was synthesized on the basis of Trost's dinuclear catalyst characterized by working well without pyridine in the present phospha-Michael reaction Nevertheless, the presence of pyridine is still advantageous in the present system The substrate scope was successfully extended to enones employing diallyl phosphine oxide as a nucleophile Excellent yields and enantioselectivities (up to >99% ee) wine achieved for a wide scope of enones employing the catalyst under mild conditions The detailed reaction mechanism is also discussed hetein Finally. the unprecedented asymmetric additions of dialkylphosphine oxides to N-sulfinylumines were achieved by using Et2Zn as a base

  DOI：

  10.1021/jo1014917

文献信息

• Asymmetric synthesis of trifluoromethylated propargylamines via 1,2-additions of trifluoromethylacetylide to N-tert-butanesulfinyl imines
  作者：Xian-Yin Chen、Xiao-Long Qiu、Feng-Ling Qing

  DOI：10.1016/j.tet.2008.01.021

  日期：2008.3

  An efficient method for the asymmetric synthesis of the trifluoromethylated propargylamines was described. Addition of lithium trifluoromethylacetylide, in situ prepared from lithium diisopropylamide and the 2-bromo-3,3,3-trifluoropropene, to various N-tert-butanesulfinyl imines provided a range of trifluoromethylated propargyl sulfinamides. Besides high yields and excellent diastereoselectivities

  描述了一种不对称合成三氟甲基化炔丙基胺的有效方法。加入锂trifluoromethylacetylide，原位从二异丙氨基锂和2-溴-3,3,3-三氟丙烯制备各种ñ -叔-butanesulfinyl亚胺提供了一系列的三氟甲基化炔丙基亚磺酰胺。除了高收率和优异的非对映选择性外，添加的特征还在于当使用极性或非极性溶剂时，非对映选择性可以逆转。叔丁烷亚磺酰基的酸性裂解可提供高度光学纯的三氟甲基化炔丙基胺。