| 1415222-81-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• CAS: 1415222-81-9
• 化学式: C₁₄H₁₉O₅P
• 分子量: 298.276
• InChiKey: VBPSTCZIZVLGRC-KBPBESRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.38
• 重原子数：
  20.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  57.29
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  在 水 、 三氟乙酸 作用下， 以 乙醚 为溶剂， 生成 (R)-(+)-2-hydroxy-2-methyl-1-indanone 、 (S)-2-hydroxy-2-methyl-1-indanone
  参考文献：
  名称：

  Asymmetric oxidation of enol phosphates to α-hydroxy ketones using Sharpless reagents and a fructose derived dioxirane

  摘要：

  The asymmetric oxidation of a variety of differently substituted, acyclic and cyclic enol phosphates using the Sharpless AD-reagents AD-mix-alpha and AD-mix-beta, and a fructose derived chiral ketone as a catalyst, afforded the corresponding alpha-hydroxy ketones in high enantioselectivity and good yield. The influence of steric and electronic factors of the substrates on the facial stereoselectivity in the reported oxidations was studied. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2012.09.012
• 作为产物：
  描述：

  phosphoric acid diethyl ester 2-methyl-3H-inden-1-yl ester 在 Oxone 、 Shi's ketone 、 四丁基氢氧化铵 、 edetate disodium 、 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 2.0h， 以28%的产率得到
  参考文献：
  名称：

  Asymmetric oxidation of enol phosphates to α-hydroxy ketones using Sharpless reagents and a fructose derived dioxirane

  摘要：

  The asymmetric oxidation of a variety of differently substituted, acyclic and cyclic enol phosphates using the Sharpless AD-reagents AD-mix-alpha and AD-mix-beta, and a fructose derived chiral ketone as a catalyst, afforded the corresponding alpha-hydroxy ketones in high enantioselectivity and good yield. The influence of steric and electronic factors of the substrates on the facial stereoselectivity in the reported oxidations was studied. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2012.09.012