1-cyclopropyl-8-[6-(cyclopropylmethylamino)pyridin-3-yl]-3-propyl-7H-purine-2,6-dione | 1000006-30-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 1-cyclopropyl-8-[6-(cyclopropylmethylamino)pyridin-3-yl]-3-propyl-7H-purine-2,6-dione
• CAS: 1000006-30-3
• 化学式: C₂₀H₂₄N₆O₂
• 分子量: 380.45
• InChiKey: TZKLPICKKSCYPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  94.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Antagonists of A2B adenosine receptors for treatment of inflammatory bowel disease
  申请人：Sitaraman Shanthi V.

  公开号：US20080176845A1

  公开（公告）日：2008-07-24

  The present invention relates to method for treating inflammatory bowel disease that includes administration of an effective amount of an antagonist of A 2B adenosine receptors (ARs).

  本发明涉及一种治疗炎症性肠病的方法，包括给予足量的A2B腺苷受体（ARs）拮抗剂。
• Substituted 8-[6-amino-3-pyridyl]xanthines
  申请人：Wang Guoquan

  公开号：US20080004292A1

  公开（公告）日：2008-01-03

  The present invention provides substituted 8-[6-amino-3-pyridyl]xanthines and pharmaceutical compositions that are selective antagonists of A 2B adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.

  本发明提供了取代的8-[6-氨基-3-吡啶基]黄嘌呤和选择性A2B腺苷受体（ARs）拮抗剂的制药组合物。这些化合物和组合物可用作药物代理。
• SUBSTITUTED 8-[6-AMINO-3PYRIDYL]XANTHINES
  申请人：Thompson Robert D.

  公开号：US20090163491A1

  公开（公告）日：2009-06-25

  The present invention provides substituted 8-[6-amino-3-pyridyl]xanthines and pharmaceutical compositions that are selective antagonists of A 2B adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.

  本发明提供了替代8-[6-氨基-3-吡啶基]黄嘌呤和药物组成物，这些物质是A2B腺苷受体（ARs）的选择性拮抗剂。这些化合物和组成物可以作为药物剂量使用。
• SUBSTITUTED 8-[6-AMINO-3-PYRIDYL]XANTHINES
  申请人：WANG Guoquan

  公开号：US20110082139A1

  公开（公告）日：2011-04-07

  The present invention provides substituted 8-[6-amino-3-pyridyl]xanthines and pharmaceutical compositions that are selective antagonists of A 2B adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
• US7875608B2
  申请人：——

  公开号：US7875608B2

  公开（公告）日：2011-01-25