tert-butyl (3-(5-(dimethylamino)naphthalene-1-sulfonamido)propyl)carbamate | 190249-84-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: tert-butyl (3-(5-(dimethylamino)naphthalene-1-sulfonamido)propyl)carbamate
• 英文别名: 3-(tert-butoxycarbonylamino)-1-(1-dimethylamino-5-naphthalene-sulfonamido)propane；tert-butyl N-[3-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]propyl]carbamate
• CAS: 190249-84-4
• 化学式: C₂₀H₂₉N₃O₄S
• 分子量: 407.534
• InChiKey: JBFATKWIECXGQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  96.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  tert-butyl (3-(5-(dimethylamino)naphthalene-1-sulfonamido)propyl)carbamate 在 盐酸 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 溶剂黄146 为溶剂， 反应 4.0h， 生成 2-Aminooxy-N-[3-(5-dimethylamino-naphthalene-1-sulfonylamino)-propyl]-acetamide; hydrochloride
  参考文献：
  名称：

  Synthesis of fluorescent probes for the detection of abasic sites in DNA

  摘要：

  The three luminescent molecules 1-3 were prepared as highly sensitive and specific probes for the quantification of a major DNA lesion, the abasic site. These molecules incorporate in their structure the reactive oxyamino function linked to the Dansyl or Lissamine-Rhodamine fluorophores through amido or polyether chains. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00235-4
• 作为产物：
  描述：

  二碳酸二叔丁酯 在 三乙胺 作用下， 以 1,4-二氧六环 、 氯仿 为溶剂， 反应 1.0h， 生成 tert-butyl (3-(5-(dimethylamino)naphthalene-1-sulfonamido)propyl)carbamate
  参考文献：
  名称：

  Synthesis of fluorescent probes for the detection of abasic sites in DNA

  摘要：

  The three luminescent molecules 1-3 were prepared as highly sensitive and specific probes for the quantification of a major DNA lesion, the abasic site. These molecules incorporate in their structure the reactive oxyamino function linked to the Dansyl or Lissamine-Rhodamine fluorophores through amido or polyether chains. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00235-4

文献信息

• Selective Chain-End Postpolymerization Reactions and Property Tuning of a Highly Conjugated and All-Thiophene Polyazomethine
  作者：Satyananda Barik、W. G. Skene

  DOI：10.1021/ma102245p

  日期：2010.12.28

  A highly conjugated polyazomethine (3) consisting uniquely of thiophenes was investigated for sustaining postpolymerization property tuning This was courtesy of the ever-present and reactive amino and aldehyde chain ends Subjecting the polymer to polymerization conditions in the absence of monomers resulted in a DPn increase from 15 to 70 The aldehyde chain end was selectively reacted with an aliphatic amine by undergoing reductive amination with sodium triacetoxyborohydride (NaBH(OAc)(3)) while the imines along the conjugated polymer framework remained Intact This illustrates the robustness of the azomethine bond Reductive amination of 3 with a monofunctional amine resulted in selective chain end capping and prevented repolymerization 3 was resistant to dynamic component exchange and monomer shuffling as a result of its high degree of conjugation Conversely chain extension was possible both by reductive amination with an alpha-omega diamine and by reheating the polymer Covalent attachment of two separate segments of 3 was possible by reductive amination with a 2 1 polymer/alpha-omega-diamine stoichiometry This resulted in molecular weight doubling and serves to illustrate the possibility of multiblock tethering via the ever active chain ends Meanwhile, a 1 1 polymer/alpha-omega-diamine stoichiometry gave rise to a polymer with an aliphatic and aromatic amine functionalized at either chain end As a result of the noncomplementary of the two chain ends the polymer could not be repolymerized However, it exhibited consistent molecular weight under various repolymerization reaction conditions indicating the robustness of the heteroconjugated bonds and their tolerance toward dynamic component exchange The color of 3 was also changed from its inherent blue color to green via the covalent attachment of a yellow dansyl derivative by reductive amination at the aldehyde chain end The collective property modification including repolymerization, coblock tethering, color modification, and increased degree of polymerization presenting unequivocal evidence that polyazomethines are capable of undergoing postpolymerization property tailoring
• [EN] ANTI-ANGIOGENIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND USE THEREOF<br/>[FR] COMPOSES ANTI-ANGIOGENIQUES, COMPOSITIONS PHARMACEUTIQUES LES COMPRENANT, ET LEUR UTILISATION
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2012104788A2

  公开（公告）日：2012-08-09

  La présente invention concerne des composés ayant une activité anti-angiogénique et/ou antitumorale, les compositions pharmaceutiques les comprenant et leur utilisation dans le traitement du cancer.