3-butyl-2-[2-(4-hydroxy-3-methoxybenzylidene)hydrazinyl]quinazolin-4(3H)-one | 1350915-77-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-butyl-2-[2-(4-hydroxy-3-methoxybenzylidene)hydrazinyl]quinazolin-4(3H)-one
• CAS: 1350915-77-3
• 化学式: C₂₀H₂₂N₄O₃
• 分子量: 366.42
• InChiKey: KUMLXXUEBUFCDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.36
• 重原子数：
  27.0
• 可旋转键数：
  7.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  88.74
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  3-butyl-2-[2-(4-hydroxy-3-methoxybenzylidene)hydrazinyl]quinazolin-4(3H)-one 在 iron(III) chloride 作用下， 以 乙醇 为溶剂， 反应 0.5h， 以85%的产率得到4-butyl-1-(4-hydroxy-3-methoxyphenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one
  参考文献：
  名称：

  Design, synthesis and in vitro PDE4 inhibition activity of certain quinazolinone derivatives for treatment of asthma

  摘要：

  In this study, a novel series of quinazolinone derivatives analogue to nitraquazone structure were synthesized. The compounds tested for their inhibitory activity against phosphodiesterase 4B revealed that compound 6d shows promising inhibitory activity comparable to that of Rolipram, whereas compounds 6a and 6c exhibited moderate inhibitory activity.

  DOI：

  10.1007/s00044-011-9846-3
• 作为产物：
  描述：

  3-丁基-2-疏基-3H-喹唑啉-4-酮 在 hydrazine hydrate 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 60.0h， 生成 3-butyl-2-[2-(4-hydroxy-3-methoxybenzylidene)hydrazinyl]quinazolin-4(3H)-one
  参考文献：
  名称：

  Design, synthesis and in vitro PDE4 inhibition activity of certain quinazolinone derivatives for treatment of asthma

  摘要：

  In this study, a novel series of quinazolinone derivatives analogue to nitraquazone structure were synthesized. The compounds tested for their inhibitory activity against phosphodiesterase 4B revealed that compound 6d shows promising inhibitory activity comparable to that of Rolipram, whereas compounds 6a and 6c exhibited moderate inhibitory activity.

  DOI：

  10.1007/s00044-011-9846-3