3-bromo-12-(4-methylphenyl)-9,9-dimethyl-8,9,10,12-tetrahydrobenzo-[a]xanthen-11-one | 1322065-50-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 新黄酮类化合物
• 英文名称: 3-bromo-12-(4-methylphenyl)-9,9-dimethyl-8,9,10,12-tetrahydrobenzo-[a]xanthen-11-one
• 英文别名: 3-bromo-9,9-dimethyl-12-(4-methylphenyl)-10,12-dihydro-8H-benzo[a]xanthen-11-one
• CAS: 1322065-50-8
• 化学式: C₂₆H₂₃BrO₂
• 分子量: 447.371
• InChiKey: DFTXGYMPMVLQTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  29
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-溴-2-萘酚 、 对甲基苯甲醛 、 5,5-二甲基-1,3-环己二酮 在 氯化铵 作用下， 反应 0.67h， 以69%的产率得到3-bromo-12-(4-methylphenyl)-9,9-dimethyl-8,9,10,12-tetrahydrobenzo-[a]xanthen-11-one
  参考文献：
  名称：

  Ammonium Chloride–Catalyzed One-Pot Synthesis of Tetrahydrobenzo[α]xanthen-11-one Derivatives Under Solvent-Free Conditions

  摘要：

  A one-pot, multicomponent reaction of aldehydes, dimedone, and beta-naphthols is described for the preparation of 12-aryl- or 12-alkyl-8,9,10,12-tetrahydrobenzo[alpha]xanthen-11-one derivatives using ammonium chloride as a mild, inexpensive, and environmentally benign catalyst under solvent-free conditions. Different types of aldehyde and beta-naphthol derivatives are used in the reaction, and in all cases the products were synthesized successfully.

  DOI：

  10.1080/00397911.2010.515340

文献信息

• Ammonium Chloride–Catalyzed One-Pot Synthesis of Tetrahydrobenzo[α]xanthen-11-one Derivatives Under Solvent-Free Conditions
  作者：Naser Foroughifar、Akbar Mobinikhaledi、Hassan Moghanian、Reza Mozafari、Hamid R. M. Esfahani

  DOI：10.1080/00397911.2010.515340

  日期：2011.9.15

  A one-pot, multicomponent reaction of aldehydes, dimedone, and beta-naphthols is described for the preparation of 12-aryl- or 12-alkyl-8,9,10,12-tetrahydrobenzo[alpha]xanthen-11-one derivatives using ammonium chloride as a mild, inexpensive, and environmentally benign catalyst under solvent-free conditions. Different types of aldehyde and beta-naphthol derivatives are used in the reaction, and in all cases the products were synthesized successfully.