2-butoxy-9-(pyrazin-2-ylmethyl)-8-methoxyadenine | 473930-05-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-butoxy-9-(pyrazin-2-ylmethyl)-8-methoxyadenine
• 英文别名: 2-Butoxy-8-methoxy-9-(pyrazin-2-ylmethyl)purin-6-amine
• CAS: 473930-05-1
• 化学式: C₁₅H₁₉N₇O₂
• 分子量: 329.362
• InChiKey: ISZCUOGGYQFEKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  114
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Novel adenne derivatives
  申请人：——

  公开号：US20040132748A1

  公开（公告）日：2004-07-08

  This invention relates to an adenine derivative, a tautomer thereof, or a pharmaceutically acceptable salt thereof represented by general formula (I): 1 wherein X represents NR 3 (wherein R 3 represents a hydrogen atom or C 1-3 alkyl) or the like; R 1 represents substituted or unsubstituted alkyl or the like; R 2 represents hydroxyl or the like; and Y represents a substituted or unsubstituted aromatic hetero ring or the like. Also, the present invention relates to pharmaceuticals such as an interferon inducer, antiviral agent, anticancer agent, type 2 helper T cell selective immune response inhibitor, antiallergic agent, and immune response modulator comprising the above derivative as an active ingredient.

  本发明涉及一种由通式（I）表示的腺嘌呤衍生物、其互变异构体或其药学上可接受的盐，其中X代表NR3（其中R3代表氢原子或C1-3烷基）或类似物；R1代表取代或未取代的烷基或类似物；R2代表羟基或类似物；Y代表取代或未取代的芳香杂环或类似物。此外，本发明还涉及将上述衍生物作为活性成分的药物，例如干扰素诱导剂、抗病毒剂、抗癌剂、2型辅助T细胞选择性免疫反应抑制剂、抗过敏剂和免疫反应调节剂。
• Novel adenine derivatives
  申请人：Isobe Yoshiaki

  公开号：US20070037832A1

  公开（公告）日：2007-02-15

  This invention relates to an adenine derivative, a tautomer thereof, or a pharmaceutically acceptable salt thereof represented by general formula (I): wherein X represents NR 3 (wherein R 3 represents a hydrogen atom or C 1-3 alkyl) or the like; R 1 represents substituted or unsubstituted alkyl or the like; R 2 represents hydroxyl or the like; and Y represents a substituted or unsubstituted aromatic hetero ring or the like. Also, the present invention relates to pharmaceuticals such as an interferon inducer, antiviral agent, anticancer agent, type 2 helper T cell selective immune response inhibitor, antiallergic agent, and immune response modulator comprising the above derivative as an active ingredient.

  本发明涉及一种腺嘌呤衍生物，其互变异构体或药学上可接受的盐，由下式表示：其中X代表NR3（其中R3代表氢原子或C1-3烷基）或类似物；R1代表取代或未取代的烷基或类似物；R2代表羟基或类似物；Y代表取代或未取代的芳香杂环或类似物。此外，本发明涉及上述衍生物作为活性成分的制备干扰素诱导剂、抗病毒剂、抗癌剂、选择性抑制2型辅助T细胞免疫反应抑制剂、抗过敏剂和免疫反应调节剂等药物。
• NOVEL ADENINE DERIVATIVES
  申请人：Dainippon Sumitomo Pharma Co., Ltd.

  公开号：EP1386923B1

  公开（公告）日：2008-08-13
• US7157465B2
  申请人：——

  公开号：US7157465B2

  公开（公告）日：2007-01-02
• US7521454B2
  申请人：——

  公开号：US7521454B2

  公开（公告）日：2009-04-21