1,2,3-Trimethyl-2-sulfanylidene-1,3,2lambda5-diazaphospholidine-4-thione | 218954-59-7

• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机硫代磷化合物
• 英文名称: 1,2,3-Trimethyl-2-sulfanylidene-1,3,2lambda5-diazaphospholidine-4-thione
• 英文别名: 1,2,3-trimethyl-2-sulfanylidene-1,3,2λ5-diazaphospholidine-4-thione
• CAS: 218954-59-7
• 化学式: C₅H₁₁N₂PS₂
• 分子量: 194.262
• InChiKey: MDYCBXUGFDPTRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  70.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,2,3-Trimethyl-2-sulfanylidene-1,3,2lambda5-diazaphospholidine-4-thione 在 硫化氢 作用下， 反应 3.0h， 生成
  参考文献：
  名称：

  Synthe`se intramole´culaire de thiopeptides N thiophosphonyle´s. Cas de la thiosarcosine

  摘要：

  A new, three-step, method is proposed for the synthesis of thiopeptides. Each step is verified starting from a sarcosylthiophosphondiamide model and using alcohols or water for the last one, With amines a different regioselective attack on the thiocarbonyl, instead of on the thiophosphoryl with alcohols, is observed. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01982-0
• 作为产物：
  描述：

  1,2,3-trimethyl-2-thioxo-2λ⁵-[1,3,2]diazaphospholidin-4-one 在 Davy's reagent 作用下， 以 甲苯 为溶剂， 以83%的产率得到1,2,3-Trimethyl-2-sulfanylidene-1,3,2lambda5-diazaphospholidine-4-thione
  参考文献：
  名称：

  Synthe`se intramole´culaire de thiopeptides N thiophosphonyle´s. Cas de la thiosarcosine

  摘要：

  A new, three-step, method is proposed for the synthesis of thiopeptides. Each step is verified starting from a sarcosylthiophosphondiamide model and using alcohols or water for the last one, With amines a different regioselective attack on the thiocarbonyl, instead of on the thiophosphoryl with alcohols, is observed. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01982-0

文献信息

• Synthe`se intramole´culaire de thiopeptides N thiophosphonyle´s. Cas de la thiosarcosine
  作者：Sonia Alibert、Dominique Crestia、Fre´de´ric Dujols、Michel Mulliez

  DOI：10.1016/s0040-4039(98)01982-0

  日期：1998.11

  A new, three-step, method is proposed for the synthesis of thiopeptides. Each step is verified starting from a sarcosylthiophosphondiamide model and using alcohols or water for the last one, With amines a different regioselective attack on the thiocarbonyl, instead of on the thiophosphoryl with alcohols, is observed. (C) 1998 Elsevier Science Ltd. All rights reserved.