1-(6-cyclohexyl-4-(pyrrolidin-1-yl)quinazolin-2-yl)-1H-pyrazole-4-carboxylic acid | 1357482-12-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1-(6-cyclohexyl-4-(pyrrolidin-1-yl)quinazolin-2-yl)-1H-pyrazole-4-carboxylic acid
• 英文别名: US10246442, Example 25；1-(6-cyclohexyl-4-pyrrolidin-1-ylquinazolin-2-yl)pyrazole-4-carboxylic acid
• CAS: 1357482-12-2
• 化学式: C₂₂H₂₅N₅O₂
• 分子量: 391.473
• InChiKey: MSPKAJJFXYLKRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  84.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] 4 - AMINOQUINAZOLIN- 2 - YL - 1 - PYRRAZOLE - 4 - CARBOXYLIC ACID COMPOUNDS AS PROLYL HYDROXYLASE INHIBITORS<br/>[FR] COMPOSÉS D'ACIDE 4-AMINOQUINAZOLIN-2-YL-1-PYRRAZOLE-4-CARBOXYLIQUE À TITRE D'INHIBITEURS DE PROLYL HYDROXYLASE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2012021830A1

  公开（公告）日：2012-02-16

  Aminoquinazolinyl compounds of formula (I) are described, which are useful as prolyl hydroxylase inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by prolyl hydroxylase activity. Thus, the compounds may be administered to treat, e.g., anemia, vascular disorders, metabolic disorders, and wound healing.

  描述了一种公式（I）的氨基喹唑啉化合物，它们可用作脯氨酸羟化酶抑制剂。这些化合物可以用于制备药物组合物和治疗由脯氨酸羟化酶活性介导的疾病状态、紊乱和病情的方法。因此，这些化合物可以被用于治疗贫血、血管紊乱、代谢紊乱和伤口愈合等疾病。
• 4-AMINOQUINAZOLIN-2-YL-1-PYRRAZOLE-4-CARBOXYLIC ACID COMPOUNDS AS PROLYL HYDROXYLASE INHIBITORS
  申请人：Rabinowitz Michael H.

  公开号：US20130143871A1

  公开（公告）日：2013-06-06

  Aminoquinazolinyl compounds of formula (I) are described, which are useful as prolyl hydroxylase inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by prolyl hydroxylase activity. Thus, the compounds may be administered to treat, e.g., anemia, vascular disorders, metabolic disorders, and wound healing.

  描述了化学式（I）的氨基喹唑啉化合物，可用作脯氨酸羟化酶抑制剂。这种化合物可用于制备药物组合物和治疗由脯氨酸羟化酶活性介导的疾病状态、紊乱和病情的方法。因此，这些化合物可用于治疗贫血、血管疾病、代谢性疾病和伤口愈合等疾病。
• 4-Aminoquinazolinyl compounds as prolyl hydroxylase inhibitors
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：US20150197507A1

  公开（公告）日：2015-07-16

  Aminoquinazolinyl compounds of formula (I) are described, which are useful as prolyl hydroxylase inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by prolyl hydroxylase activity. Thus, the compounds may be administered to treat, e.g., anemia, vascular disorders, metabolic disorders, and wound healing.

  描述了式(I)的氨基喹唑啉化合物，其作为丙氨酸羟化酶抑制剂是有用的。这样的化合物可以用于药物组合物和治疗由丙氨酸羟化酶活性介导的疾病状态、紊乱和病况的方法。因此，这些化合物可以被用于治疗贫血、血管紊乱、代谢紊乱和创伤愈合等疾病。
• 4-Aminoquinazolin compounds as prolyl hydroxylase inhibitors
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：US10246442B2

  公开（公告）日：2019-04-02

  Aminoquinazolinyl compounds of formula (I) are described, which are useful as prolyl hydroxylase inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by prolyl hydroxylase activity. Thus, the compounds may be administered to treat, e.g., anemia, vascular disorders, metabolic disorders, and wound healing.

  描述了式 (I) 的氨基喹唑啉化合物、 可用作脯氨酰羟化酶抑制剂。此类化合物可用于治疗由脯氨酰羟化酶活性介导的疾病状态、紊乱和病症的药物组合物和方法中。因此，这些化合物可用于治疗贫血、血管疾病、代谢紊乱和伤口愈合等。
• 4-aminoquinazolinyl compounds as prolyl hydroxylase inhibitors
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：US10975062B2

  公开（公告）日：2021-04-13

  Aminoquinazolinyl compounds of formula (I) are described, which are useful as prolyl hydroxylase inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by prolyl hydroxylase activity. Thus, the compounds may be administered to treat, e.g., anemia, vascular disorders, metabolic disorders, and wound healing.

  描述了式 (I) 的氨基喹唑啉化合物、 可用作脯氨酰羟化酶抑制剂。此类化合物可用于治疗由脯氨酰羟化酶活性介导的疾病状态、紊乱和病症的药物组合物和方法中。因此，这些化合物可用于治疗贫血、血管疾病、代谢紊乱和伤口愈合等。