2-[(2,2-dimethylpropyl)({[(9H-fluoren-9-yl)methoxy]carbonyl})amino]acetic acid | 1935967-49-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2-[(2,2-dimethylpropyl)({[(9H-fluoren-9-yl)methoxy]carbonyl})amino]acetic acid
• 英文别名: 2-[2,2-dimethylpropyl(9H-fluoren-9-ylmethoxycarbonyl)amino]acetic acid
• CAS: 1935967-49-9
• 化学式: C₂₂H₂₅NO₄
• 分子量: 367.4
• InChiKey: RGDOHFRHWYUDCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• EP0531443A4
  申请人：——

  公开号：EP0531443A4

  公开（公告）日：1993-04-21
• METHODS FOR TREATING INFLAMMATION AND COMPOUNDS AND COMPOSITIONS SUITABLE FOR USE THEREIN
  申请人：WEITZBERG, Moshe

  公开号：EP0531443A1

  公开（公告）日：1993-03-17
• CYCLIC PEPTIDES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF THE PLATELET ADHESION
  申请人：SANOFI

  公开号：EP2598157B1

  公开（公告）日：2016-10-12
• SPECIFIC INHIBITORS AND ACTIVE SITE PROBES FOR LEGUMAIN
  申请人：Lee Jiyoun

  公开号：US20120251459A1

  公开（公告）日：2012-10-04

  Compounds which specifically inhibit legumain, also known as asparaginyl endopeptidase are provided. The compounds have an epoxide or N-Michael acceptor warhead, and have an asparagine side chain attached to a nitrogen atom in the backbone adjacent the warhead. The compounds also preferably comprise a proline residue adjacent the asparagine, and the compound may also contain a third residue and/or a label for cellular or in vivo imaging of active legumain.
• US5079260A
  申请人：——

  公开号：US5079260A

  公开（公告）日：1992-01-07