4-benzylthioquinazoline | 6956-67-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-benzylthioquinazoline
• 英文别名: 4-benzylsulfanyl-quinazoline；4-Benzylthio-quinazoline；4-(Benzylthio)-chinazolin；4-benzylsulfanylquinazoline
• CAS: 6956-67-8
• 化学式: C₁₅H₁₂N₂S
• 分子量: 252.34
• InChiKey: QJZTVGMLKDNEMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  51.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-羟基喹唑啉 在 吡啶 、 氢氧化钾 、 tetraphosphorus decasulfide 、 四丁基溴化铵 作用下， 以 环己烷 为溶剂， 反应 20.0h， 生成 4-benzylthioquinazoline
  参考文献：
  名称：

  Quinazoline derivatives with antitubercular activity

  摘要：

  4-Quinazolinol was prepared by the reaction of anthranilic acid and formamide. The hydroxy group was converted into the thiol function by treatment with phosphorus(V)sulfide, and the subsequent alkylation of the thiol group was carried out with alkylhalides under the conditions of phase-transfer catalysis. The structure of the substances was confirmed by H-1, C-13 NMR, IR, and MS. Most of the synthesized compounds exhibited antimycobacterial activity against the strains of Mycobacterium tuberculosis, Mycobacerium avium, Mycobacterium fortuitum, Mycobacterium kansasii and Mycobacterium intracellulare. 4-(S-Butylthio)quinazoline (3c) was even more active than isoniazide against atypical strains of mycobacteria. (C) 2000 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(00)00100-2

文献信息

• 4-Thioquinazoline derivatives as antiulcer agents
  申请人：Nisshin Flour Milling Co., Ltd.

  公开号：US04829069A1

  公开（公告）日：1989-05-09

  4-Thioquinazoline derivatives of formula (I) are provided. ##STR1## wherein R.sup.1 is a C.sub.1 -C.sub.6 alkylamino group, a phenyl group, a substituted phenyl group or a 5- or 6-membered heterocyclic group containing one or two N, O or S as a hetero atom or atoms, said heterocyclic group optionally being substituted or fused with a benzene ring; n is 1 or 2; or R.sup.2 is a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group, and pharmaceutically acceptable acid addition salts thereof. They are useful as antiulcer agents.

  提供式(I)的4-硫喹噁唑衍生物。其中R.sup.1是C.sub.1-C.sub.6烷基氨基、苯基、取代苯基或含有一个或两个N、O或S作为杂原子的5-或6-成员杂环基，所述杂环基可以选择性地被苯环取代或融合；n为1或2；或R.sup.2是氢原子或C.sub.1-C.sub.6烷基基团，以及其药学上可接受的酸盐。它们可用作抗溃疡剂。
• 4-Thioquinazoline derivatives, processes for their preparation and pharmaceutical compositions
  申请人：NISSHIN FLOUR MILLING CO., LTD.

  公开号：EP0285089A2

  公开（公告）日：1988-10-05

  4-Thioquinazoline derivatives of formula (I) are provided. wherein R¹ is a C₁-C₆ alkylamino group, a phenyl group, a substituted phenyl group or a 5- or 6-membered heterocyclic group containing one or two N, O or S as a hetero atom or atoms, said heterocyclic group optionally being substituted or fused with a benzene ring; n is 1 or 2; or R² is a hydrogen atom or a C₁-C₆ alkyl group, and pharmaceutically acceptable acid addition salts thereof. They are useful as antiulcer agents.

  提供了式(I)的4-硫代喹唑啉衍生物。 其中 R¹ 是 C₁-C₆烷基氨基、苯基、取代的苯基或含有一个或两个 N、O 或 S 作为杂原子的 5 或 6 元杂环基团，所述杂环基团可选择被取代或与苯环融合；n 是 1 或 2；或 R² 是氢原子或 C₁-C₆ 烷基，及其药学上可接受的酸加成盐。它们可用作抗溃疡剂。
• Nagasaki, Izuru; Matsumoto, Miyuki; Yamashita, Masanori, Heterocycles, 1999, vol. 51, # 5, p. 1015 - 1024
  作者：Nagasaki, Izuru、Matsumoto, Miyuki、Yamashita, Masanori、Miyashita, Akira

  DOI：——

  日期：——
• TAKAHASHI, TOSHIHIRO;NAKAMARU, KOICHI;SUZUKI, YOSHIKUNI;HORAGUCHI, TATSUO
  作者：TAKAHASHI, TOSHIHIRO、NAKAMARU, KOICHI、SUZUKI, YOSHIKUNI、HORAGUCHI, TATSUO

  DOI：——

  日期：——
• US4829069A
  申请人：——

  公开号：US4829069A

  公开（公告）日：1989-05-09