4β,5α-dihydαoxycholestane-3β,6β-diyl diacetate | 76183-25-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 4β,5α-dihydαoxycholestane-3β,6β-diyl diacetate
• 英文别名: 4β,5α-dihydroxy-5α-cholestane-3β,6β-diacetate；5α-cholestane-3β,4β,5,6β-tetraol 3,6-diacetate
• CAS: 76183-25-0
• 化学式: C₃₁H₅₂O₆
• 分子量: 520.75
• InChiKey: SPNPHKBGNMUNLH-TXLFSDQGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.67
• 重原子数：
  37.0
• 可旋转键数：
  7.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  93.06
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  4β,5α-dihydαoxycholestane-3β,6β-diyl diacetate 在 lipase AY 、 sodium hydroxide 作用下， 以 乙醇 、 二氯甲烷 、 水 、 甲苯 为溶剂， 反应 24.0h， 生成 4β,5α,6β-trihydroxycholestan-3β-yl acetate
  参考文献：
  名称：

  Selective Cytotoxicity of Oxysterols through Structural Modulation on Rings A and B. Synthesis, in Vitro Evaluation, and SAR

  摘要：

  Chemically diverse oxysterols were prepared and evaluated for cytotoxicity, aiming to push forward potency and selectivity. They were tested against seven cancer (HT-29, HepG2, A549, PC3, LAMA-84, MCF-7, and SH-SYSY) and two noncancerous cell lines (ARPE-19 and BJ). The influence of the oxidation pattern on rings A and B was studied. Oxygen functionalities on ring B, such as oxo, oxime, acetamide, acetate, and alkoxy, were evaluated. Most oxysterols were cytotoxic in the low micromolar range, with emphasis to the tetrols 14 and 34, the 6 beta methoxy and acetoxy derivatives 21 and 45, and the oxime 28. In general, the oxysterols were more toxic to cancer cells and a set of compounds (9, 14, 21, 28, 45) with very high selectivity was identified. The cytotoxicity of 3 beta-acetates was lower than that of the parent alcohols, although incubation for a longer period rendered them equally cytotoxic, pointing them as potential prodrugs of oxysterols.

  DOI：

  10.1021/jm200803d
• 作为产物：
  描述：

  5α,6α-epoxycholestane-3β,4β-diyl diacetate 在 bismuth(lll) trifluoromethanesulfonate 作用下， 以 丙酮 为溶剂， 以79%的产率得到4β,5α-dihydαoxycholestane-3β,6β-diyl diacetate
  参考文献：
  名称：

  Selective Cytotoxicity of Oxysterols through Structural Modulation on Rings A and B. Synthesis, in Vitro Evaluation, and SAR

  摘要：

  Chemically diverse oxysterols were prepared and evaluated for cytotoxicity, aiming to push forward potency and selectivity. They were tested against seven cancer (HT-29, HepG2, A549, PC3, LAMA-84, MCF-7, and SH-SYSY) and two noncancerous cell lines (ARPE-19 and BJ). The influence of the oxidation pattern on rings A and B was studied. Oxygen functionalities on ring B, such as oxo, oxime, acetamide, acetate, and alkoxy, were evaluated. Most oxysterols were cytotoxic in the low micromolar range, with emphasis to the tetrols 14 and 34, the 6 beta methoxy and acetoxy derivatives 21 and 45, and the oxime 28. In general, the oxysterols were more toxic to cancer cells and a set of compounds (9, 14, 21, 28, 45) with very high selectivity was identified. The cytotoxicity of 3 beta-acetates was lower than that of the parent alcohols, although incubation for a longer period rendered them equally cytotoxic, pointing them as potential prodrugs of oxysterols.

  DOI：

  10.1021/jm200803d

文献信息

• Narayanan, C. R.; Landge, A. B., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1993, vol. 32, # 2, p. 299 - 302
  作者：Narayanan, C. R.、Landge, A. B.

  DOI：——

  日期：——
• Ishiguro, Masaji; Saito, Hiromitsu; Hirano, Yutaka, Journal of the Chemical Society. Perkin transactions I, 1980, p. 2503 - 2506
  作者：Ishiguro, Masaji、Saito, Hiromitsu、Hirano, Yutaka、Ikekawa, Nobuo

  DOI：——

  日期：——