4-(N-benzyl-N-methylamino)quinazoline | 490021-57-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-(N-benzyl-N-methylamino)quinazoline
• 英文别名: N-Benzyl-N-methylquinazolin-4-amine；N-benzyl-N-methylquinazolin-4-amine
• CAS: 490021-57-3
• 化学式: C₁₆H₁₅N₃
• 分子量: 249.315
• InChiKey: GFTXPPPMKXYHEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  29
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-羟基喹唑啉 在 六氯环三磷腈 、 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 反应 17.0h， 生成 4-(N-benzyl-N-methylamino)quinazoline
  参考文献：
  名称：

  An efficient HCCP-mediated direct amination of quinazolin-4(3H)-ones

  摘要：

  An efficient direct amination of quinazolin-4(3H)-ones has been developed. Treatment of quinazolin-4(3H)-ones with HCCP, DIPEA, and N-contained nucleophiles in acetonitrile could be able to form the corresponding 4-aminoquinazoline derivatives. Under the optimal reaction conditions, the amination products were achieved in good yields. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.12.067

文献信息

• An efficient HCCP-mediated direct amination of quinazolin-4(3H)-ones
  作者：Zhenlu Shen、Xiaofei He、Jialiang Dai、Weimin Mo、Baoxiang Hu、Nan Sun、Xinquan Hu

  DOI：10.1016/j.tet.2010.12.067

  日期：2011.3

  An efficient direct amination of quinazolin-4(3H)-ones has been developed. Treatment of quinazolin-4(3H)-ones with HCCP, DIPEA, and N-contained nucleophiles in acetonitrile could be able to form the corresponding 4-aminoquinazoline derivatives. Under the optimal reaction conditions, the amination products were achieved in good yields. (C) 2011 Elsevier Ltd. All rights reserved.