bis-2,3-(4-methoxyphenyl)sulphanyl-1,4-naphthalenedione | 89477-84-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: bis-2,3-(4-methoxyphenyl)sulphanyl-1,4-naphthalenedione
• 英文别名: bis-2,3-(4-methylphenyl)sulphanyl-1,4-naphthalenedione；2,3-Bis-(4-methoxy-phenylmercapto)-α-naphthochinon；1,4-Naphthalenedione, 2,3-bis[(4-methoxyphenyl)thio]-；2,3-bis[(4-methoxyphenyl)sulfanyl]naphthalene-1,4-dione
• CAS: 89477-84-9
• 化学式: C₂₄H₁₈O₄S₂
• 分子量: 434.537
• InChiKey: QMQKTJBMOPHURH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  103
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2,3-di-(4-methoxyphenyl)sulphanyl-1,4-naphthalenediol 在 氧气 、 copper(II) acetate monohydrate 作用下， 以 甲醇 为溶剂， 反应 5.0h， 以97%的产率得到bis-2,3-(4-methoxyphenyl)sulphanyl-1,4-naphthalenedione
  参考文献：
  名称：

  Synthesis of Mixed Aryl 2,3-Diarylsulphanyl-1,4-naphthoquinones

  摘要：

  The reaction of 2-arylsulphanyl-1,4-napththoquinone with aromatic thiols and sodium dithionate leads to bis-2,3-(arylsulphanyl)naphthalene-1,4-diols in high yield. Corresponding oxidized products, namely 2,3-diarylsulphanyl-1,4-naphthoquinones, are prepared in near quantitative yield by a copper(II)-catalyzed aerial oxidation reaction of bis-2,3-(arylsulphanyl)naphthalene-1,4-diols under mild condition.

  DOI：

  10.1080/00397910802528951

文献信息

• OERIU, Pharmazie, 1961, vol. 16, p. 320 - 327
  作者：OERIU

  DOI：——

  日期：——
• Synthesis and evaluation of antifungal activity of naphthoquinone derivatives
  作者：Giaccomo Errante、Grazia La Motta、Catarina Lagana、Vierle Wittebolle、Marie-Élisabeth Sarciron、Roland Barret

  DOI：10.1016/j.ejmech.2006.02.003

  日期：2006.6

  3-Arylamino-2-phenylsulfinylnaphthoquinones, 2,3-diarylthio-naphthoquinones and 2-phenylsulfinyl-3-arylthio-1,4-dihydronaphtalenes are synthesized and tested against five fungi. The activities of these products were better than amphotericine B against all the strains except for Candida albicans. (c) 2006 Elsevier SAS. All rights reserved.