4-(3-fluoro-4-hydroxy-phenyl)-butyric acid | 588-25-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-(3-fluoro-4-hydroxy-phenyl)-butyric acid
• 英文别名: 4-(3-Fluor-4-hydroxy-phenyl)-buttersaeure；4-(3-Fluoro-4-hydroxyphenyl)butyric acid；4-(3-fluoro-4-hydroxyphenyl)butanoic acid
• CAS: 588-25-0
• 化学式: C₁₀H₁₁FO₃
• mdl: MFCD00189391
• 分子量: 198.194
• InChiKey: UKBRLKIGCWRGBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氟苯甲醚 在 氢氧化钾 、 三氯化铝 、 一水合肼 、 二乙二醇 作用下， 反应 2.0h， 生成 4-(3-fluoro-4-hydroxy-phenyl)-butyric acid
  参考文献：
  名称：

  New Fluorine-containing Aromatics as Potential Carcinostats

  摘要：

  DOI：

  10.1021/jo01353a028

文献信息

• SALTS OF PAROXETINE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP1091958A1

  公开（公告）日：2001-04-18
• OXADIAZOLE DERIVATIVES AS RHO-KINASE INHIBITORS
  申请人：Chiesi Farmaceutici S.p.A.

  公开号：US20200331912A1

  公开（公告）日：2020-10-22

  The invention relates to compounds of formula (I) inhibiting Rho Kinase that are oxidazole derivatives, processes for preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
• [EN] SALTS OF PAROXETINE<br/>[FR] SELS DE PAROXETINE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2000001692A1

  公开（公告）日：2000-01-13

  Piperidine compounds, processes for preparing them, pharmaceutical compositions comprising them and their use in therapy are disclosed.
• New Fluorine-containing Aromatics as Potential Carcinostats
  作者：NG. PH. BUU-HOÏ、N. D. XUONG、R. RIPS

  DOI：10.1021/jo01353a028

  日期：1957.2