N-(3,5-dichloro-1-oxopyridin-4-yl)-[1-(4-fluorobenzyl)-7-oxo-7-azaindol-3-yl]glyoxylic acid amide | 785815-39-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: N-(3,5-dichloro-1-oxopyridin-4-yl)-[1-(4-fluorobenzyl)-7-oxo-7-azaindol-3-yl]glyoxylic acid amide
• 英文别名: N-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-2-[1-[(4-fluorophenyl)methyl]-7-oxidopyrrolo[2,3-b]pyridin-7-ium-3-yl]-2-oxoacetamide
• CAS: 785815-39-6
• 化学式: C₂₁H₁₃Cl₂FN₄O₄
• 分子量: 475.263
• InChiKey: SQHCVXNMBMMUGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  AWD-12-353 在 溶剂黄146 、 间氯过氧苯甲酸 、 potassium carbonate 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 168.0h， 以9.4%的产率得到N-(3,5-dichloropyridin-4-yl) [1-(4-fluorobenzyl)-7-oxo-7-azaindol-3-yl]glyoxylic acid amide
  参考文献：
  名称：

  WO2004/94416

  摘要：

  公开号：

文献信息

• EP1613627A1
  申请人：——

  公开号：EP1613627A1

  公开（公告）日：2006-01-11
• JP2006524209A
  申请人：——

  公开号：JP2006524209A

  公开（公告）日：2006-10-26
• 7-azaindoles and the use thereof as therapeutic agents
  申请人：——

  公开号：US20040224971A1

  公开（公告）日：2004-11-11

  The invention relates to substituted 7-azaindoles, process for their preparation, pharmaceutical preparations which comprise these compounds, and the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active ingredients for the treatment of disorders which can be influenced by inhibition of phosphodiesterase 4 activity in particular in immunocompetent cells (e.g. macrophages and lymphocytes) by the compounds of the invention.
• 7-Azaindoles and the use thereof as therapeutic agents
  申请人：Hofgen Nobert

  公开号：US20070161671A1

  公开（公告）日：2007-07-12

  The invention relates to substituted 7-azaindoles, process for their preparation, pharmaceutical preparations which comprise these compounds, and the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active ingredients for the treatment of disorders which can be influenced by inhibition of phosphodiesterase 4 activity in particular in immunocompetent cells (e.g. macrophages and lymphocytes) by the compounds of the invention.
• US7211583B2
  申请人：——

  公开号：US7211583B2

  公开（公告）日：2007-05-01