1-Ethyl-7-fluoro-8-[4-(4-fluorobenzyl)piperazin-1-yl]-4-oxo-1,4-dihydrobenzo[b][1,8]-naphthyridine-3-carboxylic Acid | 278796-02-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1-Ethyl-7-fluoro-8-[4-(4-fluorobenzyl)piperazin-1-yl]-4-oxo-1,4-dihydrobenzo[b][1,8]-naphthyridine-3-carboxylic Acid
• 英文别名: 1-Ethyl-7-fluoro-8-[4-(4-fluorobenzyl)piperazin-1-yl]-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid；1-ethyl-7-fluoro-8-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]-4-oxobenzo[b][1,8]naphthyridine-3-carboxylic acid
• CAS: 278796-02-4
• 化学式: C₂₆H₂₄F₂N₄O₃
• 分子量: 478.498
• InChiKey: QZAPMPLEEQBCDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  77
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  8-chloro-1-ethyl-7-fluoro-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid 、 1-(4-氟苄基)哌嗪 在 1-Ethyl-7-fluoro-8-[4-(4-fluorobenzyl)piperazin-1-yl]-4-oxo-1,4-dihydrobenzo[b][1,8]-naphthyridine-3-carboxylic Acid 、 N,N-二甲基甲酰胺 、 solid 作用下， 以1.4 g of 1-ethyl-7-fluoro-8-[4-(4-fluorobenzyl)piperazin-1-yl]-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid were obtained in the form of a yellow solid melting at about 286-8° C.的产率得到1-Ethyl-7-fluoro-8-[4-(4-fluorobenzyl)piperazin-1-yl]-4-oxo-1,4-dihydrobenzo[b][1,8]-naphthyridine-3-carboxylic Acid
  参考文献：
  名称：

  Novel benzo[1,8]naphthyridine derivatives, their preparation and pharmaceutical compositions which comprise them

  摘要：

  这是一句英文句子，翻译成中文如下： 通式为(I)的1,8-苯并萘啶衍生物是一种有用的抗微生物剂。

  公开号：

  US20020037891A1
• 作为试剂：
  描述：

  8-chloro-1-ethyl-7-fluoro-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid 、 1-(4-氟苄基)哌嗪 在 1-Ethyl-7-fluoro-8-[4-(4-fluorobenzyl)piperazin-1-yl]-4-oxo-1,4-dihydrobenzo[b][1,8]-naphthyridine-3-carboxylic Acid 、 N,N-二甲基甲酰胺 、 solid 作用下， 以1.4 g of 1-ethyl-7-fluoro-8-[4-(4-fluorobenzyl)piperazin-1-yl]-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid were obtained in the form of a yellow solid melting at about 286-8° C.的产率得到1-Ethyl-7-fluoro-8-[4-(4-fluorobenzyl)piperazin-1-yl]-4-oxo-1,4-dihydrobenzo[b][1,8]-naphthyridine-3-carboxylic Acid
  参考文献：
  名称：

  Benzo[1,8]naphthyridine derivatives, their preparation and pharmaceutical compositions which comprise them

  摘要：

  Novel 1,8-苯并萘啶衍生物的一般式(I)：可用作抗微生物剂。

  公开号：

  US06548506B2

文献信息

• Novel benzo[1,8]naphthyridine derivatives, their preparation and pharmaceutical compositions which comprise them
  申请人：——

  公开号：US20020037891A1

  公开（公告）日：2002-03-28

  Novel 1,8-benzo-naphthyridine derivatives of general formula (I): 1 which are useful as antimicrobial agents.

  一种通式（I）的新型1,8-苯并萘啉衍生物，可用作抗微生物药物。
• US6548506B2
  申请人：——

  公开号：US6548506B2

  公开（公告）日：2003-04-15
• Benzo[1,8]naphthyridine derivatives, their preparation and pharmaceutical compositions which comprise them
  申请人：Aventis Pharma S.A.

  公开号：US06548506B2

  公开（公告）日：2003-04-15

  Novel 1,8-benzo-naphthyridine derivatives of general formula (I): which are useful as antimicrobial agents.

  Novel 1,8-苯并萘啶衍生物的一般式(I)：可用作抗微生物剂。