| 1228260-28-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• CAS: 1228260-28-3
• 化学式: C₁₃H₂₅FO
• 分子量: 216.339
• InChiKey: DOKZZURSNGTTBZ-CLLJXQQHSA-N

反应信息

• 作为产物：
  描述：

  异戊醛 、 烯丙基三甲基硅烷 在 四氟硼酸-二乙醚络合物 作用下， 以 二氯甲烷 为溶剂， 反应 45.0h， 以78%的产率得到
  参考文献：
  名称：

  HBF4·OEt2 as a versatile reagent for the Hosomi–Sakurai allylation and Prins cyclization: one-pot synthesis of symmetrical 4-fluorotetrahydropyrans

  摘要：

  The synthesis of symmetrical 2,6-disubstituted 4-fluorotetrahydropyran derivatives has been achieved using HBF4 center dot OEt2 via a tandem allylation and Prins cyclization. This is a highly efficient and diastereoselective approach for the preparation of 4-fluorotetrahydropyrans in a single step. The use of readily available and easy to handle reagent HBF4 center dot OEt2 makes this method simple, convenient and practical. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.03.082