2-(tert-butyl-dimethyl-silanyl)-4-(hydroxy-naphthalen-2-yl-methyl)-imidazole-1-sulfonic acid dimethylamide | 880782-87-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(tert-butyl-dimethyl-silanyl)-4-(hydroxy-naphthalen-2-yl-methyl)-imidazole-1-sulfonic acid dimethylamide
• 英文别名: 2-[tert-butyl(dimethyl)silyl]-4-[hydroxy(naphthalen-2-yl)methyl]-N,N-dimethylimidazole-1-sulfonamide
• CAS: 880782-87-6
• 化学式: C₂₂H₃₁N₃O₃SSi
• 分子量: 445.658
• InChiKey: VZPNTKMSIFEONH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.49
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  83.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(tert-butyl-dimethyl-silanyl)-4-(hydroxy-naphthalen-2-yl-methyl)-imidazole-1-sulfonic acid dimethylamide 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以80%的产率得到4-(hydroxy-naphthalen-2-yl-methyl)-imidazole-1-sulfonic acid dimethylamide
  参考文献：
  名称：

  4-(Condensed cyclicmethyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists

  摘要：

  Formula 1的化合物，其中变量的含义如规范中所定义的，是alpha2肾上腺素受体的激动剂。本公开的若干化合物是特异性或选择性地作用于alpha2B和/或alpha2C肾上腺素受体，而不是alpha2A肾上腺素受体。此外，一些所述的化合物几乎没有心血管和/或镇静作用，或者仅有极小的作用。Formula 1的化合物在哺乳动物中，包括人类，作为治疗对alpha2肾上腺素受体激动剂有响应的疾病和/或症状缓解的药物是有用的。具有无显著心血管和/或镇静作用的Formula 1的化合物可用于治疗疼痛和其他症状，具有最小的副作用。

  公开号：

  US20060069144A1
• 作为产物：
  描述：

  2-萘甲醛 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 17.0h， 以50%的产率得到2-(tert-butyl-dimethyl-silanyl)-4-(hydroxy-naphthalen-2-yl-methyl)-imidazole-1-sulfonic acid dimethylamide
  参考文献：
  名称：

  4-(Condensed cyclicmethyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists

  摘要：

  Formula 1的化合物，其中变量的含义如规范中所定义的，是alpha2肾上腺素受体的激动剂。本公开的若干化合物是特异性或选择性地作用于alpha2B和/或alpha2C肾上腺素受体，而不是alpha2A肾上腺素受体。此外，一些所述的化合物几乎没有心血管和/或镇静作用，或者仅有极小的作用。Formula 1的化合物在哺乳动物中，包括人类，作为治疗对alpha2肾上腺素受体激动剂有响应的疾病和/或症状缓解的药物是有用的。具有无显著心血管和/或镇静作用的Formula 1的化合物可用于治疗疼痛和其他症状，具有最小的副作用。

  公开号：

  US20060069144A1

文献信息

• 4-(Condensed cyclicmethyl)-imidazole-2-thiones acting as α2 adrenergic agonists
  申请人：Allergan, Inc.

  公开号：US07396849B2

  公开（公告）日：2008-07-08

  Compounds of Formula 1 where the variables have the meaning defined in the specification are agonists of alpha2 adrenergic receptors. Several compounds of the disclosure are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors. Additionally some of the claimed compounds have no or only minimal cardivascular and/or sedatory activity. The compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2 adrenergic receptors. Compounds of Formula 1 which have no significant cardiovascular and/or sedatory activity are useful for treating pain and other conditions with minimal side effects.

  式1的化合物，其中变量的含义在说明书中定义，是α2肾上腺素受体的激动剂。本公开的几种化合物在选择性上特异或选择性地作用于α2B和/或α2C肾上腺素受体，而不是α2A肾上腺素受体。此外，一些所述的化合物没有或只有极小的心血管和/或镇静活性。式1的化合物在哺乳动物中，包括人类，用于治疗对α2肾上腺素受体激动剂有反应的疾病和/或缓解条件中是有用的。没有显著心血管和/或镇静活性的式1的化合物可用于治疗疼痛和其他具有最小副作用的病症。
• 4-(condensed cyclicmethyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists
  申请人：Allergan, Inc.

  公开号：US07838545B2

  公开（公告）日：2010-11-23

  Compounds of Formula 1 where the variables have the meaning defined in the specification are agonists of alpha2 adrenergic receptors. Several compounds of the disclosure are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors. Additionally some of the claimed compounds have no or only minimal cardiovascular and/or sedatory activity. The compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2 adrenergic receptors. Compounds of Formula 1 which have no significant cardiovascular and/or sedatory activity are useful for treating pain and other conditions with minimal side effects.

  式1的化合物，其中变量具有说明书中定义的含义，是α2肾上腺素受体的激动剂。本公开的几种化合物对α2B和/或alpha2C肾上腺素受体具有特异性或选择性，而优先于alpha2A肾上腺素受体。此外，一些声称的化合物没有或只有最小的心血管和/或镇静活性。式1的化合物在哺乳动物，包括人类中，用于治疗对α2肾上腺素受体激动剂有反应的疾病和/或缓解条件是有用的。具有无显著心血管和/或镇静活性的式1的化合物可用于治疗疼痛和其他具有最小副作用的情况。
• 4-(CONDENSED CYCLICMETHYL)-IMIDAZOLE-2-THIONES ACTING AS ALPHA2 ADRENERGIC AGONISTS
  申请人：Heidelbaugh Todd M.

  公开号：US20090176828A1

  公开（公告）日：2009-07-09

  Compounds of Formula 1 where the variables have the meaning defined in the specification are agonists of alpha 2 adrenergic receptors. Several compounds of the disclosure are specific or selective to alpha 2B and/or alpha 2C adrenergic receptors in preference over alpha 2A adrenergic receptors. Additionally some of the claimed compounds have no or only minimal cardiovascular and/or sedatory activity. The compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha 2 adrenergic receptors. Compounds of Formula 1 which have no significant cardiovascular and/or sedatory activity are useful for treating pain and other conditions with minimal side effects.

  式1的化合物，其中变量的含义在规范中定义，是alpha2肾上腺素受体的激动剂。本公开的几种化合物是特异性或选择性地作用于alpha2B和/或alpha2C肾上腺素受体，而不是alpha2A肾上腺素受体。此外，一些所述的化合物没有或只有极小的心血管和/或镇静作用。式1的化合物可用作哺乳动物，包括人类的药物，用于治疗对alpha2肾上腺素受体激动剂有反应的疾病和/或缓解条件。没有明显心血管和/或镇静作用的式1的化合物可用于治疗疼痛和其他具有最小副作用的疾病。
• 4-(Condensed cyclicmethyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists
  申请人：Heidelbaugh M. Todd

  公开号：US20060069144A1

  公开（公告）日：2006-03-30

  Compounds of Formula 1 where the variables have the meaning defined in the specification are agonists of alpha 2 adrenergic receptors. Several compounds of the disclosure are specific or selective to alpha 2B and/or alpha 2C adrenergic receptors in preference over alpha 2A adrenergic receptors. Additionally some of the claimed compounds have no or only minimal cardivascular and/or sedatory activity. The compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha 2 adrenergic receptors. Compounds of Formula 1 which have no significant cardiovascular and/or sedatory activity are useful for treating pain and other conditions with minimal side effects.

  Formula 1的化合物，其中变量的含义如规范中所定义的，是alpha2肾上腺素受体的激动剂。本公开的若干化合物是特异性或选择性地作用于alpha2B和/或alpha2C肾上腺素受体，而不是alpha2A肾上腺素受体。此外，一些所述的化合物几乎没有心血管和/或镇静作用，或者仅有极小的作用。Formula 1的化合物在哺乳动物中，包括人类，作为治疗对alpha2肾上腺素受体激动剂有响应的疾病和/或症状缓解的药物是有用的。具有无显著心血管和/或镇静作用的Formula 1的化合物可用于治疗疼痛和其他症状，具有最小的副作用。