9-isobutyl-3,9-dihydro-purine-2,6-dione | 121475-05-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-isobutyl-3,9-dihydro-purine-2,6-dione
• 英文别名: 9-Isobutyl-3,9-dihydro-purin-2,6-dion；9-(2-methylpropyl)-3H-purine-2,6-dione
• CAS: 121475-05-6
• 化学式: C₉H₁₂N₄O₂
• 分子量: 208.22
• InChiKey: ZTTIUIRNGWIZHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  9-isobutyl-8-thio-uric acid 在 sodium hydroxide 、 镍 作用下， 生成 9-isobutyl-3,9-dihydro-purine-2,6-dione
  参考文献：
  名称：

  Potential Purine Antagonists. XI. Synthesis of Some 9-Aryl(alkyl)-2,6-disubstituted Purines

  摘要：

  DOI：

  10.1021/ja01544a044

文献信息

• Benzoheterocyclic carbamates
  申请人：USV PHARMACEUTICAL CORPORATION

  公开号：EP0116938A1

  公开（公告）日：1984-08-29

  Compounds of the structure; and pharmaceutically acceptable salts thereof, wherein: R and R, are each H, alkyl, alkoxy, carboxy, alkylcarboxy, trifluoromethyl, halogen, nitro or hydroxy; X is 0, N, S or C; Y is 0, N or S; and R2 is H, alkyl, cycloalkyl, aryl or heteroaryl useful in the treatment of ischemic heart disease and hypertriglyceridemia.

  结构的化合物； 及其药学上可接受的盐类，其中 R和R各自是H、烷基、烷氧基、羧基、烷基羧基、三氟甲基、卤素、硝基或羟基； X 是 0、N、S 或 C； Y 是 0、N 或 S；以及 R2 是 H、烷基、环烷基、芳基或杂芳基，用于治疗缺血性心脏病和高甘油三酯血症。
• ADIPONECTIN INCREASING AGENT
  申请人：SUNTORY LIMITED

  公开号：EP1731521A1

  公开（公告）日：2006-12-13

  An adiponectin enhancer comprising as an active ingredient sesamin and/or episesamin, or an analogue thereof.

  一种由芝麻素和/或表芝麻素或其类似物作为活性成分的脂肪生成素促进剂。
• Preprimitive streak and mesendoderm cells
  申请人：VIACYTE, INC.

  公开号：EP2341147A2

  公开（公告）日：2011-07-06

  This disclosure relates to compositions comprising human preprimitive streak cells and/or human mesendoderm cells as well as methods for their production. Additionally, disclosed herein are methods of identifying factors useful in the further differentiation of preprimitive streak and mesendoderm cell types.

  本公开涉及包含人原始条纹细胞和/或人中胚层细胞的组合物及其生产方法。此外，本文还公开了鉴定有助于原始条纹细胞和中胚层细胞进一步分化的因子的方法。
• CD49F PROMOTING PROLIFERATION, MULTIPOTENCY AND REPROGRAMMING OF ADULT STEM CELLS THROUGH PI3K/AKT/GSK3 PATHWAY
  申请人：Kang Stem Holdings Co., Ltd

  公开号：EP2537922A2

  公开（公告）日：2012-12-26

  The present invention relates to a method for obtaining adult stem cells, which have a surface antigen of CD49f, excellent formation of spheres due to sphere formation and high expression of OCT4 and SOX2, from a cell source including stem cells, and a cell therapeutic agent containing adult stem cells obtained by the method or cells differentiated therefrom as an active ingredient. According to the present invention, adult stem cells derived from spheres are suitable for mass culture of adult stem cells because of more rapid growth thereof compared with stem cells obtained by a known adhesive culture method, have a specific surface antigen so as to be homogeneously obtained by using the specific surface antigen, and are useful for preparing a cell therapeutic agent using the same because of excellent differentiation thereof.

  本发明涉及一种从包括干细胞在内的细胞源中获得成体干细胞的方法，这种成体干细胞具有CD49f的表面抗原，由于球形形成和OCT4和SOX2的高表达而具有良好的球形形成，以及一种含有通过该方法获得的成体干细胞或由其分化的细胞作为活性成分的细胞治疗剂。 根据本发明，从球体中提取的成体干细胞适用于成体干细胞的大规模培养，因为与通过已知的粘附培养方法获得的干细胞相比，其生长速度更快，具有特异性表面抗原，可通过使用特异性表面抗原均匀获得，并且由于其分化性能优异，可用于制备细胞治疗剂。
• Method for preparing induced paraxial mesoderm progenitor (iPAM) cells and their use
  申请人：INSERM (Institut National de la Santé et de la Recherche Médicale)

  公开号：EP2565264A1

  公开（公告）日：2013-03-06

  The present invention relates to an ex vivo method for preparing a population of induced paraxial mesoderm progenitor (iPAM) cells, said method comprising the step of culturing pluripotent cells in an appropriate culture medium comprising an effective amount of an activator of the Wnt signalling pathway.

  本发明涉及一种制备诱导性轴旁中胚层祖细胞（iPAM）群体的体外方法，所述方法包括以下步骤：在适当的培养基中培养多能细胞，培养基中含有有效量的 Wnt 信号通路激活剂。