6-bromo-2-(4-(3-(trifluoromethyl)pyridin-2-yl)phenyl)-1H-imidazo[4,5-b]pyridine | 904305-98-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 6-bromo-2-(4-(3-(trifluoromethyl)pyridin-2-yl)phenyl)-1H-imidazo[4,5-b]pyridine
• 英文别名: 6-bromo-2-[4-[3-(trifluoromethyl)pyridin-2-yl]phenyl]-1H-imidazo[4,5-b]pyridine
• CAS: 904305-98-2
• 化学式: C₁₈H₁₀BrF₃N₄
• 分子量: 419.203
• InChiKey: HKVZDXKFZLUOEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  54.5
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• NOVEL METHOD OF PREPARING BENZOIMIDAZOLE DERIVATIVES
  申请人：Kim In Woo

  公开号：US20130231477A1

  公开（公告）日：2013-09-05

  This invention relates to a method of preparing a benzoimidazole derivative at high purity and high yield so as to enable the production of the benzoimidazole derivative compound as an antagonist against a vanilloid reactor-1, and particularly to a method of preparing a benzoimidazole derivative at high purity and high yield, wherein the benzoimidazole derivative is synthesized using a novel intermediate, namely, benzaldehyde, and thereby the preparation process is simple so that it can be applied to production.

  本发明涉及一种制备苯并咪唑衍生物的方法，使其具有高纯度和高产率，从而能够生产苯并咪唑衍生物化合物作为对vanilloid受体-1的拮抗剂，并特别涉及一种制备苯并咪唑衍生物的方法，其中苯并咪唑衍生物是使用一种新颖的中间体，即苯甲醛合成的，因此制备过程简单，可以应用于生产中。
• Novel Benzoimidazole Derivatives and Pharmaceutical Composition Comprising the Same
  申请人：Kim Ji Duck

  公开号：US20090018124A1

  公开（公告）日：2009-01-15

  Disclosed herein are novel benzoimidazole derivatives functioning as antagonists to vanilloid receptor-1, and a pharmaceutical composition comprising the same. They are useful in preventing or treating pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraines, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, strokes, bladder hypersensitivity, irritable bowel syndrome, respiratory disorders such as asthma, chronic obstructive pulmonary disease, etc., burns, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases.

  本发明涉及一种新型苯并咪唑衍生物，其作为vanilloid receptor-1的拮抗剂，以及包含它们的药物组合物。它们可用于预防或治疗疼痛、急性疼痛、慢性疼痛、神经痛、术后疼痛、偏头痛、关节痛、神经病、神经损伤、糖尿病神经病、神经系统疾病、神经性皮炎、中风、膀胱过敏、肠易激综合征、哮喘、慢性阻塞性肺疾病等呼吸系统疾病、烧伤、牛皮癣、瘙痒、呕吐、皮肤、眼睛和黏膜刺激、胃十二指肠溃疡、炎性肠病和炎性疾病。
• US9040572B2
  申请人：——

  公开号：US9040572B2

  公开（公告）日：2015-05-26
• US9199965B2
  申请人：——

  公开号：US9199965B2

  公开（公告）日：2015-12-01
• [EN] NOVEL METHOD OF PREPARING BENZOIMIDAZOLE DERIVATIVES<br/>[FR] NOUVEAU PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE BENZOIMIDAZOLE
  申请人：DAE WOONG PHARMA

  公开号：WO2012044043A2

  公开（公告）日：2012-04-05

  This invention relates to a method of preparing a benzoimidazole derivative at high purity and high yield so as to enable the production of the benzoimidazole derivative compound as an antagonist against a vanilloid reactor-1, and particularly to a method of preparing a benzoimidazole derivative at high purity and high yield, wherein the benzoimidazole derivative is synthesized using a novel intermediate, namely, benzaldehyde, and thereby the preparation process is simple so that it can be applied to production.