(E)-methyl 3-(cyclohexylamino)-2-(1-phenylprop-1-en-2-yl)imidazo[1,2-a]pyridine-7-carboxylate | 1311992-00-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: (E)-methyl 3-(cyclohexylamino)-2-(1-phenylprop-1-en-2-yl)imidazo[1,2-a]pyridine-7-carboxylate
• CAS: 1311992-00-3
• 化学式: C₂₄H₂₇N₃O₂
• 分子量: 389.497
• InChiKey: QNQAQXASIPQEIQ-BMRADRMJSA-N

物化性质

• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.43
• 重原子数：
  29.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.63
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  2-氨基异烟酸甲酯 、 异氰环已烷 、 反式-alpha-甲基肉桂醛 在 scandium tris(trifluoromethanesulfonate) 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以46%的产率得到(E)-methyl 3-(cyclohexylamino)-2-(1-phenylprop-1-en-2-yl)imidazo[1,2-a]pyridine-7-carboxylate
  参考文献：
  名称：

  Combinatorial Discovery of Fluorescent Pharmacophores by Multicomponent Reactions in Droplet Arrays

  摘要：

  Fluorescence imaging in clinical diagnostics and biomedical research relies to a great extent on the use of small organic fluorescent probes. Because of the difficulty of combining fluorescent and molecular-recognition properties, the development of such probes has been severely restricted to a number of well-known fluorescent scaffolds. Here we demonstrate that autofluorescing druglike molecules are a valuable source of bioimaging probes. Combinatorial synthesis and screening of chemical libraries in droplet microarrays allowed the identification of new types of fluorophores. Their concise and clean assembly by a multicomponent reaction presents a unique potential for the one-step synthesis of thousands of structurally diverse fluorescent molecules. Because they are based upon a druglike scaffold, these fluorophores retain their molecular recognition potential and can be used to design specific imaging probes.

  DOI：

  10.1021/ja204016e

文献信息

• Combinatorial Discovery of Fluorescent Pharmacophores by Multicomponent Reactions in Droplet Arrays
  作者：Olga N. Burchak、Laurent Mugherli、Mariano Ostuni、Jean Jacques Lacapère、Maxim Y. Balakirev

  DOI：10.1021/ja204016e

  日期：2011.7.6

  Fluorescence imaging in clinical diagnostics and biomedical research relies to a great extent on the use of small organic fluorescent probes. Because of the difficulty of combining fluorescent and molecular-recognition properties, the development of such probes has been severely restricted to a number of well-known fluorescent scaffolds. Here we demonstrate that autofluorescing druglike molecules are a valuable source of bioimaging probes. Combinatorial synthesis and screening of chemical libraries in droplet microarrays allowed the identification of new types of fluorophores. Their concise and clean assembly by a multicomponent reaction presents a unique potential for the one-step synthesis of thousands of structurally diverse fluorescent molecules. Because they are based upon a druglike scaffold, these fluorophores retain their molecular recognition potential and can be used to design specific imaging probes.