1,5-bis(2-naphthyl)-3-pentanone | 71492-52-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1,5-bis(2-naphthyl)-3-pentanone
• 英文别名: 1,5-Dinaphthalen-2-ylpentan-3-one
• CAS: 71492-52-9
• 化学式: C₂₅H₂₂O
• 分子量: 338.449
• InChiKey: RFAPMBUSXDHVFO-UHFFFAOYSA-N

物化性质

• 沸点：
  527.9±19.0 °C(predicted)
• 密度：
  1.136±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,5-bis(2-naphthyl)-3-pentanone 在 sodium hydroxide 、 肼 作用下， 以 various solvent(s) 为溶剂， 生成 1,5-bis(2-naphthyl)pentane
  参考文献：
  名称：

  Time-resolved observation of excitation hopping between two identical chromophores attached to both ends of alkanes

  摘要：

  DOI：

  10.1021/ja00233a004
• 作为产物：
  描述：

  2-萘甲醛 在 sodium hydroxide 、 溶剂黄146 、 锌 作用下， 以 乙醇 为溶剂， 反应 1.0h， 生成 1,5-bis(2-naphthyl)-3-pentanone
  参考文献：
  名称：

  Time-resolved observation of excitation hopping between two identical chromophores attached to both ends of alkanes

  摘要：

  DOI：

  10.1021/ja00233a004

文献信息

• [EN] EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DES RECEPTEURS D'ACIDES AMINES EXCITATEURS
  申请人：ELI LILLY AND COMPANY

  公开号：WO1996007405A1

  公开（公告）日：1996-03-14

  (EN) The present invention provides compounds of formula (I) in which R is as defined in the specification, or a pharmaceutically acceptable metabolically labile ester or amide thereof, or a pharmaceutically acceptable salt thereof, which are useful as antagonists of one or more of the actions of L-glutamate at metabotropic excitatory amino acid receptors.(FR) Cette invention concerne des composés de formule (I), dans laquelle R est tel que défini dans le descriptif, ou un ester ou amide pharmaceutiquement acceptable de ces composés qui est métaboliquement labile, ou encore un sel pharmaceutiquement acceptable de ces composés, qu'on utilise comme antagonistes d'une ou de plusieurs actions du L-glutamate au niveau des récepteurs d'acides aminés excitateurs métabotropiques.

  本发明提供了公式（I）的化合物，其中R如规范中定义，或其药物可接受的代谢易裂解酯或酰胺，或其药物可接受的盐，这些化合物是L-谷氨酸在代谢型兴奋性氨基酸受体上的一个或多个作用的拮抗剂。
• Structural and Spatial Considerations in the <i>N</i>,<i>N</i>′-Diacyl- and Bis(alkoxycarbonyl)bispidinone Series
  作者：Shlomo Levinger、Yifat Sharabi-Ronen、Alexander Mainfeld、Amnon Albeck

  DOI：10.1021/jo801423a

  日期：2008.10.3

  Diamidic and dicarbamic bispidinones show trans-cis isomerism, the relative population in solution of the cis form increasing with solvent polarity. The mutual proximity of the two amide functions in 4a has no impact on the barrier to isomerization. The system represents a peculiar case of planar chirality posing a challenge to its specification.
• Antibacterial N-[.omega.,.omega.'-bis(alicyclic and aryl)-sec-alkyl]poly(methylenetriamine and -tetramine) hydrochloride salts
  作者：N. Grier、R. A. Dybas、R. A. Strelitz、B. E. Witzel、E. L. Dulaney

  DOI：10.1021/jm00197a024

  日期：1979.11

  A series of antibacterial N-(omega, omega'-(cycloalkyl, bicyclo[2.2.1]heptyl, and alkyl-substituted phenyl)-sec-alkyl]poly(methylene)triamine and -tetramine hydrochloride salts were synthesized in an effort to develop efficient, nonsystemic inhibitors, particularly for Pseudomonas aeruginosa. In the 1,5,9-triazanonane group, 3 of 16 compounds were effective at 8--10 micrograms/mL against pseudomonads. Efficiency appeared more dependent upon lipophilicity of the nitrogen substituent than other characteristics represented by the three types of rings. A parabolic relationship was observed for the entire set between the hydrophobic parameter, pi, of the lipoidal moiety and minimal inhibitory concentration. One of 16 tetramines, 1-[1,5-bis(3,3-dimethyl-2-norbornyl)-3-pentyl]-1,5,9,13-tetraazatridecane tetrahydrochloride (26f), ranked similarly. An additional two compounds in each series were superior to several commercial cationic detergents in the control of the Gram-negative bacteria. None was inhibitory at up to 200 micrograms/mL for Proteus vulgaris.
• EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS
  申请人：ELI LILLY AND COMPANY

  公开号：EP0771196A1

  公开（公告）日：1997-05-07
• EP0771196A4
  申请人：——

  公开号：EP0771196A4

  公开（公告）日：1997-09-03