(S)-6-amino-2-((5-(dimethylamino)naphthalene)-1-sulfonamido)hexanamide | 1312667-81-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (S)-6-amino-2-((5-(dimethylamino)naphthalene)-1-sulfonamido)hexanamide
• CAS: 1312667-81-4
• 化学式: C₁₈H₂₆N₄O₃S
• 分子量: 378.495
• InChiKey: BCTHXXGCYOORHY-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.17
• 重原子数：
  26.0
• 可旋转键数：
  9.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  118.52
• 氢给体数：
  3.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  N-[1-[(2R,3S,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]pyrazolo[3,4-d]pyrimidin-4-yl]-2-methylpropanamide 、 丹酰氯 在 哌啶 、 三乙胺 、 三异丙基硅烷 、 三氟乙酸 作用下， 以 N,N-二甲基甲酰胺 、 水 为溶剂， 反应 3.0h， 生成 (S)-6-amino-2-((5-(dimethylamino)naphthalene)-1-sulfonamido)hexanamide
  参考文献：
  名称：

  Two dansyl fluorophores bearing amino acid for monitoring Hg2+ in aqueous solution and live cells

  摘要：

  A series of compounds (1-4) bearing one or two dansyl fluorophore(s) based on a Lys amino acid were synthesized in solid phase synthesis. Among them, two dansyl labeled Lys amino acid 3 detected Hg2+ in a 100% aqueous solution with high sensitivity (K-d=4.3 nM) via a turn-on response. Compound 3 was applied for monitoring Hg2+ in environmental and biological fields. 3 showed a hypersensitive response to Hg2+ without interferences from other metal ions and satisfied the requirements for monitoring the maximum allowable level (2 ppb) of mercury ions in drinking water demanded by EPA. In addition, 3 penetrated living HeLa cells and detected intracellular Hg2+. The organic spectroscopic data revealed the two sulfonamide and amide groups of 3 played a key role in stabilizing the 3-Hg2+ complex. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.03.106